Ecology with Emphasis on the Environment

kao Mitsuaki Nishibuchi,Ph.D.   btn

Pathogenic microorganisms are important risk factors in the environment and influence human health.  The factors in the natural environment influence the emergence of infectious diseases through the effects on survival and propagation of pathogenic microorganisms.  Socioeconomic factors in the human-life environment influence spread of infectious diseases through their effects on contact between pathogens and humans, resistance of individuals as well as the community, etc.  In addition, these factors may influence to each other.  We analyze how various factors interact with individual pathogens and the infection using an ecological approach.

Research and Education

We make GSS graduate students learn the approach for comprehensive analysis of factors important in understanding emergence and spread of infectious diseases. They include those in the natural environment where pathogens persist, the human environment, , and human resistance to pathogens.
We carry out studies in Southeast Asian and the surrounding countries in collaboration with local researchers. We isolate Vibrio cholerae, Vibrio parahaemolyticus, and Escherichia coli O157 from the environmental and clinical specimens and investigate the factors affecting the emergence of the infectious diseases by comparative and comprehensive analyses of the isolated bacteria and the environmental and clinical data.
We also study the infectious diseases that are able to spread internationally.  The phylogenetic relationships among the isolates from various areas will lead to elucidation of the epidemiology of infection.  Investigation of the relationship between the phylogeny of the isolates and international movement of humans and commodities, e.g., food, carrying the pathogens, will often help reveal the factors involved in transmission of infectious diseases.

r-105-1 Graduate students of our group teach specialized laboratory techniques to young Asian scientists and Kyoto University in our laboratory as a part of a field study program of The Inter-Graduate School Program (GSS)(December, 2012)

r-105-2 Interview on food poisoning cases at Ministry of Health, Singapore as a part of a field study program of The Inter-Graduate School Program (GSS)(March, 2013)

Recent Publications

  1. Escalante-Maldonado, O., et al. 2015. Improvement of the quantitation method for the tdh+ Vibrio parahaemolyticus in molluscan shellfish based on most-probable- number, immunomagnetic separation, and loop-mediated isothermal amplification. Front. Microbiol. doi: 10.3389/fmicb.2015.00270.
  2. Yingkajorn M., et al. 2014. Vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (Anadara granosa) for the risk of V. parahaemolyticus infection in southern Thailand. Microbil. Ecol. 67(4): 849-856
  3. Sermwittayawong N., et al. 2012. Human Plasmodium knowlesi infection in Ranong province, southwestern border of Thailand. Malaria Journal 11:36 (
  4. Loo, Y. Y. et al. 2012. Synthesis of silver nanoparticles by using tea leaf extract from Camellia sinensis. Int. J. Nanomedicine 7:4263-4267.
  5. Chen, Y., et al. 2011. Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence. BMC Genomics 12(1): 294.


Professor: Mitsuaki Nishibuchi
Specific Assistant Professor: Kayali Ahamad Yaman
TEL:075-753-7367, 7319; 075-761-2700
FAX:075-753-7319; 075-761-2701