Our proximate goal is to analyze gene-environmental interactions for development of adverse health effects. As environmental factors, radiation, atmosphere, persistent organic pollutants, nutrition and working conditions are within our research scope. Laboratory works, genetic epidemiology and field studies are routinely used to solve the problems. Our long-term goal is to practice preventive measures based on our findings. Candidates with public health mind, from any disciplines, will be welcome.
Research and Education
We are exposed to various health hazards. These are found in routine life styles, diets, environmental pollutants and occupational settings. Changes in environment always have revealed new phenotypes and brought new public health issues. To build rational preventive measures, both susceptive genetic determinants and environmental factors should be taken into account. On this basis, we would like to conduct public health practices.
Currently, following projects are ongoing. In the first project, we are assessing levels of exposure to persistent organic pollutants in a 30-year span and analyze them for disease risk in various cohort studies. In this project, we are building the Environmental Specimen Bank which is open to the public. We study also the radiation exposure caused by Fukushima Daiichi nuclear disaster and health effects due to lifestyle changes in evacuees. The second, Infantile Episodic Lib Pain is another target for gene-environmental (atmospheric) interaction. We have also analyzed pathogenesis of Moyamoya disease in our laboratory from a viewpoint of preventive medicine against brain infarction and breeding in the childhood.
Multiple aspects for health sciences (Genetic factor, Environment and Lifestyles)
Field works in Fukusima, Japan
- Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Pare G, O’Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, Debette S, Kubo M, Koizumi A, Ihara M. Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis. Circulation 2019;139:295-8.
- Kabata R, Okuda H, Noguchi A, Kondo D, Fujiwara M, Hata K, Kato Y, Ishikawa K, Tanaka M, Sekine Y, Hishikawa N, Mizukami T, Ito J, Akasaka M, Sakurai K, Yoshida T, Minoura H, Hayashi T, Inoshita K, Matsuyama M, Kinjo N, Cao Y, Inoue S, Kobayashi H, Harada KH, Youssefian S, Takahashi T, Koizumi A. Familial episodic limb pain in kindreds with novel Nav1.9 mutations. PLoS One 2018;13:e0208516.
- Ebner DK, Ohsawa M, Igari K, Harada KH, Koizumi A. Lifestyle-related diseases following the evacuation after the Fukushima Daiichi nuclear power plant accident: a retrospective study of Kawauchi Village with long-term follow-up. BMJ Open 2016;6:e011641.
- Shiwaku Y, Lee P, Thepaksorn P, Zheng B, Koizumi A, Harada KH. Spatial and temporal trends in perfluorooctanoic and perfluorohexanoic acid in well, surface, and tap water around a fluoropolymer plant in Osaka, Japan. Chemosphere 2016;164:603-10.
- Harada KH, Niisoe T, Imanaka M, Takahashi T, Amako K, Fujii Y, Kanameishi M, Ohse K, Nakai Y, Nishikawa T, Saito Y, Sakamoto H, Ueyama K, Hisaki K, Ohara E, Inoue T, Yamamoto K, Matsuoka Y, Ohata H, Toshima K, Okada A, Sato H, Kuwamori T, Tani H, Suzuki R, Kashikura M, Nezu M, Miyachi Y, Arai F, Kuwamori M, Harada S, Ohmori A, Ishikawa H, Koizumi A. Radiation dose rates now and in the future for residents neighboring restricted areas of the Fukushima Daiichi Nuclear Power Plant. Proc Natl Acad Sci USA 2014; 111: E914-23.
Health and Environmental SciencesAssociate Professor: Kouji Harada
Assistant Professor: Hiroko Okuda