Rehabilitation Science for Bone and Joint Disorders

Hiroshi Kuroki,
P.T., Ph.D., Professor


Our laboratory investigates development of locomotorium and nervous system deficits and how therapeutic exercises and physical therapy modalities could address those issues. We use several animal models to perform multiple-aspect analysis.
We foster human resources who are able to propose novel rehabilitation regimens to clinical situations based on new evidences obtained from these studies. Moreover, in order to develop a field of regenerative rehabilitation, which is a novel and emerging wisdom, we cooperate with Kyoto University Hospital and Center for iPS Cell Research and Application (CiRA) etc.

Research and Education

Our laboratory is currently working on the following three research projects.

1) Study on effects of mechanical stimuli and exercises on tissue degeneration and regeneration. (Kuroki and Ito)
To develop physical therapy for joint disorders such as osteoarthritis (Fig. 1A) and peripheral nerve injury (Fig. 1B), we are trying to clarify the therapeutic effects and its action mechanisms of exercises and physical therapy modalities using several animal models. In addition, we are developing a motor function analysis method for rodents by means of three-dimensional motion analysis system that is applicable to clinical situations. (Fig. 1C).

2) Regenerative Rehabilitation researches. (Kuroki and Ito)
To keep up with recent development in regenerative medicine, it is urgent to establish relevant rehabilitation regimens. We work as a member of international consortium for regenerative rehabilitation; in particular we work on basic researches for articular cartilage, peripheral nerve, and central nervous system (Fig 2).

3) Study of psychology and behavior modification in elderly care. (Maeda)
Figure 1A. Study of joint disorders
Figure 1B. Study of peripheral nerve injury
Figure 1C. Development of motor function analysis with a three-dimensional motion analysis for rodents
Figure 2. Regenerative Rehabilitation researches

Recent Publications

  1. Kiyan W, Nakagawa Y, Ito A, Iijima H, Nishitani H, Tanima-Nagai M, Mukai S, Tajino J, Yamaguchi S, Nakahata A, Zhang J, Aoyama T, Kuroki H. Ultrasound Parameters for Human Osteoarthritic Subchondral Bone Ex Vivo: Comparison with Micro-Computed Tomography Parameters. Ultrasound Med Biol. 2018 Oct;44(10):2115-2130.
  2. Tajino J, Ito A, Nagai M, Yamaguchi S, Iijima H, Nakahata A, Kiyan W, Aoyama T, Kuroki H. Three-dimensional motion analysis for comprehensive understanding of gait characteristics after sciatic nerve lesion in rodents. Sci Rep. 2018;8:135852018.
  3. Iijima H, Isho T, Kuroki H, Takahashi M, Aoyama T. Effectiveness of mesenchymal stem cells for treating patients with knee osteoarthritis: a meta-analysis toward the establishment of effective regenerative rehabilitation. npj Regenerative Medicine. 2018;3:15.
  4. Wang T, Ito A, Aoyama T, Nakahara R, Nakahata A, Ji X, Zhang J, Kawai H, Kuroki H. Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis. PLoS One. 2018 Dec 12;13(12):e0208985.
  5. Iijima H, Ito A, Nagai M, Tajino J, Yamaguchi S, Kiyan W, Nakahata A, Zhang J, Wang T, Aoyama T, Nishitani K, Kuroki H. Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model. Osteoarthritis Cartilage. 2017 Jun;25(6):964-975.


Professor : Hiroshi Kuroki, P.T., Ph.D.
Senior Lecturer : Yuko Maeda, Ph.D.
Assistant Professor : Akira Ito, P.T., Ph.D.

TEL:075  – 751  – 3963(Kuroki) 3917(Maeda) 3964(Ito)
FAX075  – 751  – 3963(Kuroki) 3917(Maeda) 3964(Ito)