Cognitive Motor Neuroscience

Therapeutic interventions focused on the activation of the central nervous system (CNS) are crucial for patients who suffer from physical disorders. Our laboratory using neurophysiological, neuropsychological, brain imaging, and three-dimensional motor analysis techniques aim to measure non-invasively the changes in the CNS excitability during cognitive and motor activities in order to develop the novel and evidence-based therapeutic programs. We aim to apply the knowledge and skills from the fundamental research to benefit the clinical treatments of patients, in other words, to perform the translational research from laboratory to clinical medicine.

Research and Education

Our laboratory aims to set forward the rehabilitation/ occupational therapy in an academic way with the education, research, and clinical practice. We engage in the lectures and practices related to the occupational therapy of physical disorders with the undergraduate students, and do researches in the specific areas of the laboratory staffs with the graduate students. Everybody interested in the rehabilitation science and neuroscience with a fervent spirit will receive a warm welcome. The details of our research interests are shown below.

・The central mechanisms for voluntary movements
・The difference and interaction between the cerebral hemispheres
・The central mechanisms and training effects of motor imagery, action observation, and kinesthetic illusion
・Anticipatory postural adjustments (APAs)
・Developments and clinical assessments of rehabilitative approaches by using virtual reality system and information-communication technology
・The brain activity during cognitive tasks including memory, attention, and executive functions
・The recovery mechanisms for patients with the nervous system diseases
・The interaction of repetitive transcranial magnetic stimulation (rTMS) and motor learning
Transcranial Magnetic Stimulation (TMS) utilized to explore non-invasively the corticospinal excitability in humans (Modified partially from the Principles of Neural Science). Measurement of brain blood flows during a Virtual Shopping Test performance.

Recent Publications

  1. Irie K, Iseki H, Okamoto S, Okamoto K, Nishimura S, Kagechika K. Development of the modified simple test for evaluating hand function (modified STEF): Construct, reliability, validity, and responsiveness. Journal of Hand Therapy 32, 388-394, 2019.
  2. Liang N, Iwamoto GA, Downey RM, Mitchell JH, Smith SA, Mizuno M. The pressor response to concurrent stimulation of the mesencephalic locomotor region and peripheral sensory afferents is attenuated in normotensive but not hypertensive rats. Frontiers in Physiology 10, 95, 2019.
  3. Okahashi S, Mizumoto H, Komae A, Ueno K, Yokoyama M, Nagano A, Seki K, Futaki T, Luo Z. Assessment of Convalescent brain-damaged patients using a virtual shopping test with different task difficulties. Journal of Pain Management 9, 301-310, 2016.
  4. Liang N, Mitchell JH, Smith SA, Mizuno M. Exaggerated sympathetic and cardiovascular responses to stimulation of the mesencephalic locomotor region in spontaneously hypertensive rats. American Journal of Physiology Heart and Circulatory Physiology 310, H123-H131, 2016.
  5. Liang N, Funase K, Takahashi M, Matsukawa K, Kasai T. Unilateral imagined movement increases interhemispheric inhibition from the contralateral to ipsilateral motor cortex. Experimental Brain Research 232, 1823-1832, 2014.


Associate Professor: Nan Liang Ph.D., OTR
Assistant Professor: Sayaka Okahashi Ph.D., OTR
Assistant Professor: Keisuke Irie Ph.D., OTR

TEL & FAX: 075-751-3973 (Liang) 3965 (Okahashi, Irie)