Ayae Kinoshita, MD, PhD, Professor
As the population ages, the need to fully understand the pathogenesis of dementia and to develop its effective method for care is vital to our nation. Therefore, the mission of our section is to help the person with the disease, and caregivers, family members to empower the abilities that remain. Within this mission, one objective is to foster new lines by bringing together basic and clinical science with an emphasis on Alzheimer’s disease and related disorders. We welcome the young scientists who have interests in dementia research.
Research and Education
1)Pathogenesis of Alzheimer’s disease
The exact nature of neuronal dysfunction in Alzheimer’s disease remains largely unknown. For the last 10 years, we have focused on the protein Presenilin 1 (PS1), a causative protein for familial Alzheimer’s disease in order to reveal its pathogenesis. We are now currently pursuing the mechanisms which influence the PS1 localization and functions. We identified several factors to regulate PS1 function and are now currently analyzing them in vitro and in vivo.
2)Development of internet-based telenursing
In order to support the homecare for the dementia patients, there is a need for the bi-directional, communicative and economical approach between the patients and the medical staff. We develop and provide a new strategy to help the dementia patients and caregivers by internet-based webcamera.
①Our research proposal. Through basic and clinical research to alleviate sporadic Alzheimer’s disease, we hope to provide quality and accessible medical care for the Alzheimer’s patients and their caregivers.
②An example of a new IT-based bi-directional support system for the dementia patients and caregivers to connect Kyoto University Hospital and patients’ home directly.
1. Kubota M, Sato Y, Khookhor O, Ekberg K, Chibalin A, Wahren J:
Enhanced insulin action following subcutaneous co-administration of insulin and C-peptide in rats
Diabetes/Metabolism Research and Reviews; in press
2. Maesako M, Uemura K, Iwata A, Kubota M, Watanabe K, Uemura M, Noda Y, Asada-Utsugi M, Kihara T, Takahashi R, Shimohama S, Kinoshita A:
Continuation of exercise is necessary to inhibit high fat diet-induced Aβ deposition and memory deficit in amyloid precursor protein transgenic mice
PLoS ONE; 8(9): e72796. 2013
3. Hiyoshi-Taniguchi K, Becker CB, Kinoshita A:
Social workers can use sense of coherence to predict burnout of end-of-life care-givers (Research report from Japan)
British Journal of Social Work; May 30: 1-15. 2013
4. Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K:
Copper enhances APP dimerization and promotes Aβ production
Neurosci Lett; Jun 28;547:10-5. 2013
5. Kubota M, Hosoda K, Eguchi K, Furuya A, Nishijima Y, Nakao K, Kinoshita A:
Videophone-based multimodal home telecare support system for patients with diabetes
Diabetology International; Mar 4 (1): 52-59. 2013
Professor ：Ayae Kinoshita
Assistant Professor ：Masakazu Kubota
E-Mail ：Ayae Kinoshita kinoshita.ayae.6v atmark kyoto-u.ac.jp
Masakazu Kubota kubota.masakazu.5w atmark kyoto-u.ac.jp