Innovative Medical Imaging Technology

MT_SensinKiki_1Naozo Sugimoto,Ph.D.(in Eng.) Professor

Among biomedical imaging technologies, image information processing applicable to various clinical applications and ultra high resolution MRI are focused in this group. Medical image data obtained from such as CT and MRI becomes larger so as to provide medical staff with higher quality images. One of our objectives is to develop image information processing algorithm and systems to assist doctors in extracting necessary information from the huge data by more precise and more effective way. In order to obtain molecular/cell level information, we are also developing the MR microscopy system.

Research and Education

Two of ongoing research themes are introduced here.
 We develop imaging and image processing techniques for quantitative analysis of multi dimensional medical images including multi modality images or sequential images. We also develop medical applications such as image guided radiotherapy, image guided intervention, and CAD(computer aided diagnosis) systems. Examples of the work are shown in the figures(Imaging and image processing for 4-dimensional cardiac MR tagged images, and MR DWI thermometry).
 We have been also developing an ultra high resolution Magnetic Resonance Imaging(MRI), “MR microscopy”. With the MR microscope we have achieved a 20 um spatial resolution in small fresh-water fish, Medaka. Medaka have attracted many attentions as a cost-effective disease model. Since various physical properties can be used as contrast mechanism in MRI, we are trying to specify tissue/cell characteristics of medaka disease models in vivo not only from anatomical information but also from the physical properties. We have started applying quantitative susceptibility mapping to the MR microscope in order to quantify tissue iron contents.

Multi dimensional image processing

Multi dimensional image processing

MR microscopy and MR microscopy images of medaka fish

MR microscopy and MR microscopy images of medaka fish



1. K. Yamada, K. Sakai, K. Akazawa, N.Sugimoto, et. al, Detection of early neuronal damage in CADASIL patients by q-space MR imaging, Neuroradiology, Vol.55, No.3, pp.283-290(2013)
2. M. Murashima, T. Ueno, K. Sakai, Y. Taniguchi, and N. Sugimoto, Postmortem 3D image comparison of wild type and p53 knockout medaka by MR microscope, Molecular Imaging and Biology, Vol.14, suppl.1, p.s378(2012)
3. K. Sakai, K. Yamada, and N. Sugimoto: Calculation methods for ventricular diffusion-weighted imaging thermometry: phantom and volunteer studies, NMR in Biomedicine, Vol.25, No.2, p.340-346(2011)
4. T. Ueno, S. Kanayama, N. Sugimoto, et al.,Development of 14.1 T MR Microscope. Molecular Imaging and Biology, 12 suppl.1, pp.S255-S256(2010)
5. S. Urayama, N. Sugimoto, et al., Four-dimensional MR tagged imaging and image processing. International Journal of Computer Assisted Radiology and Surgery, Vol. 1-Suppl., pp.107-109(2006)


Professor: Naozo Sugimoto
Assistant Professor: Tomohiro Ueno
Program-Specific Senior Lecturer: Koji Sakai

TEL 075-751-4993
FAX 075-751-3909