Laboratory of Biophysics

MT_Biophysics_1 Akitoshi Seiyama, Ph.D. Professor

We are developing new technologies to visualize biophysical and physiological functions inside the living body, especially to visualize human brain function. Further, we aim to reveal mechanisms of such individual bio-phenomena through animal experiments.

Research and Education

We are developing new technologies to visualize biophysical and physiological functions inside the living body. In vivo molecular imaging, an important technique in the post-genome strategy, has the potential to visualize the dynamics of individual bio-phenomena processes in cells, organs as well as in the living body. We aim to reveal mechanisms of such individual bio-phenomena in the living body through bio-imaging using MRI, Near-IR optical imaging and electrophysiological techniques.

Physiological background of neuroimaging and their techniques.

Physiological background of neuroimaging and their techniques.


Optical assessment of brain function in animal models.

Optical assessment of brain function in animal models.

 

Publications

1. Ueshima C, Kataoka TR, Hirata M, Koyanagi I, Honda T, Tsuruyama T, Okayama Y, Seiyama A, Haga H. NKp46 regulates the production of serine proteases and IL-22 in human mast cells in urticaria pigmentosa. Exp. Dermatol. 2015 May 2. doi: 10.1111/exd.12741.

2. Ooi Y, Inui-Yamamoto C, Suzuki T, Nakadate H, Nagase Y, Seiyama A, Yoshioka Y, Seki J. In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats. Brain Res. 1579: 84-92, 2014.

3. Yoshida M, Origuchi M, S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto  S, Miyauchi S, Fukuyama H, Seiyama A. fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training. NeuroImage: Clinical 5: 161-168, 2014

4. Oonishi S, Hori S, Hoshi Y, Seiyama A. Influence of subjective happiness on the prefrontal brain activity: an fNIRS study. Adv. Exp. Med. Biol. 812: 287-293, 2014

5. Seiyama A, Yoshikawa N, Imamura Y. Ischemic pretreatment delays ischemic brain vasospasm injury in gerbils. Adv. Exp. Med. Biol. 812: 247-252, 2014

Laboratory

Professor: Akitoshi Seiyama Ph.D.

E-mail: aseiyama@hs.med.kyoto-u.ac.jp