Laboratory of Pathology

MT_Byori_1 Tetsuya Takakuwa, MD, PhD, Professorbtn

Many people – some scientists, others not – are interested in early human development because it is closely
related to the basic and important question: What are we and where have we come from? We analyze the three-dimensional morphogenesis of the human embryos using various materials. Most of the specimens are between the 3rd and 8th week following fertilization, which is the critical period of teratogenesis.
The etiology and pathogenetic mechanisms of congenital anomalies remain to be clarified for most birth defects. We investigate the causes and pathogenesis of birth defects using interdisciplinary research approaches.

Research and Education

Insights into the dynamic and complex processes during organogenesis will require accurate morphologic data with dynamic modeling of embryonic structures. especially, 3D reconstructions are necessary to elucidate the complex anatomic remodeling that occurs during these early embryonic stages. In this aspects, morphogenesis during early human embryonic periods, both normal and abnormal, has been precisely analysed using the MR image data, histological sections, and the novel image data such as EFIC and pcCT. Those embryo and materials derived from the “Kyoto Collection” which is the the largest collection of human embryo specimens in the world, stored at the Congenital Anomaly Research Center. The obtained data will contribute to a better understanding of morphogenesis of human embryo, and serve as a useful reference for fetal medicine and prenatal diagnosis.The pathologic basis of diseases is educated for the faculty students. The advanced course for medical technologist in the graduate school was provided who will learn diagnostic cytology, ultrasonography in obstetrics and gynecology, and basic human basic anatomy on practice.



1. Shiraishi N, Nakashima T, Yamada S, Uwabe C, Kose K, Takakuwa T, Morphogenesis of lateral choroid plexus during human embryonic period, Anatomical Records, in press
2. Hamabe Y, Hirose A, Yamada S, Takakuwa T et al, Morphology and Morphometry of Fetal Liver at 16–26 Weeks of Gestation by Magnetic Resonance Imaging – Comparison with Embryonic Liver at Carnegie Stage 23, Hepatol Res, in press
3. Kagurasho M, Yamada S, Takakuwa T et al, Movement of the external ear in human embryo, Head Face Med. 2012 Feb 1;8(1):2.
4. Nakashima T, Yamada S, Takakuwa T et al, Morphometric analysis of the brain vesicles during the human embryonic period by magnetic resonance microscopic imaging, Congenit Anom (Kyoto). 2012 Mar;52(1):55-8.
5. Hirose A, Yamada S, Takakuwa T et al, Embryonic liver morphology and morphometry by magnetic resonance microscopic imaging , Anat Rec (Hoboken). 2012 Jan;295(1):51-9.


Professor: Tetsuya Takakuwa MD, PhD

Human Health Science, Graduate School of Medicine, Kyoto University
606-8507 Sakyo-ku Shogoin Kawahara-cyo 53, Kyoto, Japan
TEL 075-751-3931/3956