Our proximate goal is to analyze gene-environmental interactions for development of adverse health effects. As environmental factors, persistent organic pollutants, nutrition and working conditions are within our research scope. Laboratory works, genetic epidemiology and field studies are routinely used to solve the problems. Our long-term goal is to practice preventive measures based on our findings. Candidates with public health mind, from any disciplines, will be welcome.
Research and Education
We are exposed to various health hazards. These are found in routine life styles, diets, environmental pollutants and occupational settings. Changes in environment always have revealed new phenotypes and brought new public health issues. To build rational preventive measures, both susceptive genetic determinants and environmental factors should be taken into account. On this basis, we would like to conduct public health practices.
Currently, following projects are ongoing. The first one is to reveal pathogenesis of Moyamoya disease. We have also analyzed in our laboratory from a viewpoint of preventive medicine against brain infarction and breeding in the childhood. Infantile Episodic Lib Pain is another target for gene-environmental (atmospheric) interaction. In the second project, we are assessing levels of exposure to persistent organic pollutants in a 30-year span. In this project, we are building the Environmental Sample Bank which is open to the public. We study also the radiation exposure caused by Fukushima Daiichi nuclear disaster and health effects due to lifestyle changes in evacuees.
Multiple aspects for health sciences (Genetic factor, Environment and Lifestyles)Field works in Fukusima, Japan
- Morimoto T, Enmi JI, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A. Dysregulation of RNF213 promotes cerebral hypoperfusion. Sci Rep 2018;8:3607.
- Ebner DK, Ohsawa M, Igari K, Harada KH, Koizumi A. Lifestyle-related diseases following the evacuation after the Fukushima Daiichi nuclear power plant accident: a retrospective study of Kawauchi Village with long-term follow-up. BMJ Open 2016;6:e011641.
- Okuda H, Noguchi A, Kobayashi H, Kondo D, Harada KH, Youssefian S, Shioi H, Kabata R, Domon Y, Kubota K, Kitano Y, Takayama Y, Hitomi T, Ohno K, Saito Y, Asano T, Tominaga M, Takahashi T, Koizumi A. Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families. PLoS One 2016;11:e0154827.
- Harada KH, Niisoe T, Imanaka M, Takahashi T, Amako K, Fujii Y, Kanameishi M, Ohse K, Nakai Y, Nishikawa T, Saito Y, Sakamoto H, Ueyama K, Hisaki K, Ohara E, Inoue T, Yamamoto K, Matsuoka Y, Ohata H, Toshima K, Okada A, Sato H, Kuwamori T, Tani H, Suzuki R, Kashikura M, Nezu M, Miyachi Y, Arai F, Kuwamori M, Harada S, Ohmori A, Ishikawa H, Koizumi A. Radiation dose rates now and in the future for residents neighboring restricted areas of the Fukushima Daiichi Nuclear Power Plant. Proc Natl Acad Sci USA 2014; 111: E914-23.
- Liu W, Morito D, Takashima S, Mineharu Y, Kobayashi H, Hitomi T, Hashikata H, Matsuura N, Yamazaki S, Toyoda A, Kikuta K, Takagi Y, Harada KH, Fujiyama A, Herzig R, Krischek B, Zou L, Kim JE, Kitakaze M, Miyamoto S, Nagata K, Hashimoto N, Koizumi A. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLOS One 2011; 6: e22542.
Health and Environmental SciencesAssociate Professor: Kouji Harada