Akio Koizumi, M.D., Ph.D. Professor
Health and Environmental Sciences
Our proximate goal is to analyze gene-environmental interactions for development of adverse health effects. As environmental factors, persistent organic pollutants, nutrition and working conditions are within our research scope. Laboratory works, genetic epidemiology and field studies are routinely used to solve the problems. Our long-term goal is to practice preventive measures based on our findings. Candidates with public health mind, from any disciplines, will be welcome.
Research and Education
We are exposed to various health hazards. These are found in routine life styles, diets, environmental pollutants and occupational settings. Changes in environment always have revealed new phenotypes and brought new public health issues. To build rational preventive measures, both susceptive genetic determinants and environmental factors should be taken into account. On this basis, we would like to conduct public health practices.
Currently, following projects are ongoing. The first one is to reveal pathogenesis of Moyamoya disease. We have also analyzed in our laboratory from a viewpoint of preventive medicine against brain infarction and breeding in the childhood. In the second project, we are assessing levels of exposure to persistent organic pollutants in a 30-year span. In this project, we are building the Environmental Sample Bank which is open to the public. We study also the radiation exposure caused by Fukushima Daiichi nuclear disaster. We have still other ongoing projects related to common diseases such as diabetes.
Multiple aspects for health sciences (Genetic factor, Environment and Lifestyles)Field works in Fukusima, Japan
- Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, Imai H, Sone M, Taura D, Harada KH, Habu T, Takagi Y, Miyamoto S, Koizumi A. Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo. J Am Heart Assoc. 2015; 4(7): e002146.
- Yan JX, Hitomi T, Takenaka K, Kato M, Kobayashi H, Okuda H, Harada KH, Koizumi A. Genetic Study of Intracranial Aneurysms. Stroke. 2015; 46: 620-626.
- Harada KH, Niisoe T, Imanaka M, Takahashi T, Amako K, Fujii Y, Kanameishi M, Ohse K, Nakai Y, Nishikawa T, Saito Y, Sakamoto H, Ueyama K, Hisaki K, Ohara E, Inoue T, Yamamoto K, Matsuoka Y, Ohata H, Toshima K, Okada A, Sato H, Kuwamori T, Tani H, Suzuki R, Kashikura M, Nezu M, Miyachi Y, Arai F, Kuwamori M, Harada S, Ohmori A, Ishikawa H, Koizumi A. Radiation dose rates now and in the future for residents neighboring restricted areas of the Fukushima Daiichi Nuclear Power Plant. Proc Natl Acad Sci USA 2014; 111: E914-23.
- Liu W, Morito D, Takashima S, Mineharu Y, Kobayashi H, Hitomi T, Hashikata H, Matsuura N, Yamazaki S, Toyoda A, Kikuta K, Takagi Y, Harada KH, Fujiyama A, Herzig R, Krischek B, Zou L, Kim JE, Kitakaze M, Miyamoto S, Nagata K, Hashimoto N, Koizumi A. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLOS One 2011; 6: e22542.
- Kobayashi H, Abe K, Matsuura T, Ikeda Y, Hitomi T, Akechi Y, Habu T, Liu W, Okuda H, Koizumi A. Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement. Am J Hum Genet 2011; 89: 121-130.
Health and Environmental SciencesProfessor: Akio Koizumi
Associate Professor: Kouji Harada
Lecturer: Hatasu Kobayashi
Researcher: Hiroko Okuda
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