Koji Kawakami, MD, PhD, Professor  btn

Clinical epidemiology, which has made remarkable progress since the 1980s, is an academic field in which researchers conduct clinical studies on various questions derived from the clinical practice, with appropriate epidemiological study design. Moreover, pharmacoepidemiology was established in the U.S. in 1980s to cover clinical epidemiology and clinical pharmacy. The research fields have expanded to outcomes research on the effects and side-effects of pharmaceuticals and biologics; economic research to evaluate the cost-effectiveness of medical treatment; and regulatory science to evaluate safety and the effects of pharmaceicals, medical devices, and diagnosis. In spite of its extremely important value, the number of researchers is too few and the research projects are not very much supported from the government funds in Japan, we strongly feel the need to promote academic activities and recruit the range of researchers to the field.
Our research group is very uniquely formed with researchers and students with a broad range of backgrounds. Various research projects are conducted based on the research questions from researchers clinical or working experiences, such as outcomes research in clinical epidemiology and pharmacoepidemiology, health technology assessment (HTA) research on cost-effectiveness of pharmaceuticals or clinical practices, and regulatory science research to evaluate safety and the effects of medicines and medical devices on development and post-market. By conducting various research and learning from other researches, we often have a forefeeling that an entirely new research field is being forged, which may incubate a new concept of value that no one ever imagined. Here, we are waiting for graduate students and young researchers who would like to expand a new medical research fields for the future health care, society, industry, and health policy.

Research and Education

Members of our laboratory are generally divided into the dry team and the wet team. The dry team focus on the clinical epidemiology/pharmacoepidemiology, health policy, and regulatory science researches. The wet team mainly conducts researches on the safety and efficacy of the newly concepted drugs such as hybrid peptide, and drug delivery system (DDS) and microscopic imaging tools for the assessment of drugs and medical devices.
Researchers and students in the dry team conduct studies based on their clinical questions or working experiences. Most of the students has experienced with physician, surgeon, anestheologist, pharmacist, or nurse. We also welcome individuals from pharmaceutical companies conducting R&D, regulatory affairs, and clinical/economical evaluation of the products; health-related industries; and government officers engaged in health or drug policymaking. We fully support students who aim to be distinguished researcher or professional in the field. The keywords for our research area are clinical epidemiology, pharmacoepidemiology, EBM, regulatory science, cost-effectiveness analysis and comparative effectiveness research (CER), health technology assessment (HTA), medical big-data, life course data. We believe our activities and alum will be highly needed from various fields in the near future.
Research in the wet field mainly include studies on anti-cancer drugs created by our invention, the hybrid peptide technique. These research activities, including next-generation drug development, are yielding vibrant studies, which are not limited to theoretical research but also include applied research, which characterizes how medical researchers distinguish themselves from other scientists in pharmacy or bioscience fields.

Summer party (July, 2017)

Development of the healthcare life course data from 70 local governments in Japan /
Medical real world database for the clinical/pharmaco-epidemiology studies

Recent Publications

  1. Yonekura H, Seto K, Ide K, Kawasaki Y, Tanaka S, Nahara I, Takeda C, Kawakami K. Preoperative blood tests conducted before low-risk surgery in Japan: a retrospective observational study using a nationwide insurance claims database. Anesthesia and Analgesia, 126:1633-1640, 2018.(Editorialにも特集)
  2. Yoshida S, Calistus W, Kimura T, Takeuchi M, Kawakami K. Prenatal alcohol exposure and suspected hearing impairment among children: a population-based retrospective cohort study. Alcohol and Alcoholism, 53:221–227, 2018.
  3. Sato I, Yamamoto Y, Kato G, Kawakami K. Potentially inappropriate medication prescribing and the risk of unplanned hospitalization among the elderly: A self-matched, case-crossover study. Drug Safety, in press, 2018.
  4. Hongyan C, Tanaka S, Arai K, Yoshida S, Kawakami K. Insufficient sleep and incidence of dental caries in deciduous teeth among children in Japan: a population-based cohort study. The Journal of Pediatrics, in press, 2018.
  5. Kimura T, Takeuchi M, Imai T, Tanaka S, Kawakami K, and Neonatal Research Network of Japan. Vaginal versus cesarean delivery for neurodevelopment at 3 years in neonates born at <26 weeks of gestation: retrospective analysis of a nationwide registry in Japan. Neonatology, 112: 258–266, 2017.


Koji Kawakami, MD, PhD, Professor and Chair
Masato Takeuchi, MD, PhD, Associate Professor
Tomohisa Horibe, PhD, Associate Professor
Izumi Sato, PhD, Assistant Professor
Satomi Yoshida, PhD, Assistant Professor
Keisuke Matsubayashi, MD, Assistant Professor
Kazuki Ide, PhD, Assistant Professor
Megumi Yuno, PhD, Assistant Professor
General contact: (Email)