Biomechanics

kaoTaiji Adachi, Professor (Engineering), Ph.D. btn

Our research group aims to clarify the mechanisms by which cells sense mechanical stimuli and regulate their activities in tissue adaptation, regeneration and stem cell differentiation in morphogenesis. To better understand the mechano-regulation of these dynamical processes through the complex hierarchical structure-function relationships, bridging spatial and temporal scales from microscopic molecular/cellular activities to macroscopic tissue behaviors is very important. Based on multiscale biomechanics, our group is involved in the integrated biomechanics and mechanobiology researches of modeling and simulation combined with experiments, focusing on mechano-biochemical couplings in the system dynamics.

Research and Education

Living systems have the ability to functionally adapt to the changing mechanical environment by remodeling their structures dynamically at the organ, tissue, cellular and molecular levels. The mechanical environment also has an enormous influence on the dynamic rearrangement of the multicellular system during morphogenesis in tissue development as well as the remodeling of intracellular structures during cell division and cell migration. To address these interdisciplinary issues from mechanical viewpoints, we are conducting biomechanics research aiming to mechanically understand structural and functional dynamics at the molecular, cellular, and tissue levels, as well as mechanobiology research aiming to elucidate these biological functions, particularly research integrating in vitro experiments, mathematical modeling and computer simulation based on mechanics. Furthermore, our goal is to create new materials and structures for regenerative medicine by integrating self-organized structures appearing in a bottom-up manner in bio-molecular systems, with nano- and micro-technologies which control their structures by a top-down engineering approach.

Fig.1:Biomechanics of Bone Functional Adaptation

Fig.2:Multiscale Computational Biomechanics on Tissue Morphogenesis


Recent Publications

  1. Koichiro Maki, Sung-Woong Han, Yoshinori Hirano, Shigenobu Yonemura, Toshio Hakoshima, Taiji Adachi, (2016), Mechano-adaptive Sensory Mechanism of α-catenin under Tension, Scientific Reports, Vol. 6, #24878.
  2. Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi, (2013), Reversible Network Reconnection Model for Simulating Large Deformation in Dynamic Tissue Morphogenesis, Biomechanics and Modeling in Mechanobiology, Vol. 12, No. 4, pp. 627-644.
  3. Mototsugu Eiraku, Nozomu Takata, Hiroki Ishibashi, Masako Kawada, Eriko Sakakura, Satoru Okuda, Kiyotoshi Sekiguchi, Taiji Adachi, Yoshiki Sasai, (2011), Self-organizing Optic-cup Morphogenesis in Three-dimensional Culture, Nature, Vol. 472, pp. 51-56.
  4. Ken-ichi Tsubota, Yusuke Suzuki, Tomonori Yamada, Masaki Hojo, Akitake Makinouchi, Taiji Adachi, (2009), Computer Simulation of Trabecular Remodeling in Human Proximal Femur Using Large-Scale Voxel FE Models: Approach to Understanding Wolff’s Law, Journal of Biomechanics, Vol. 42, No. 8, pp. 1088-1094.
  5. Taiji Adachi, Yuki Osako, Mototsugu Tanaka, Masaki Hojo, Scott J. Hollister, (2006), Framework for Optimal Design of Porous Scaffold Microstructure by Computational Simulation of Bone Regeneration, Biomaterials, Vol. 27, No. 21, pp. 3964-3972.

Laboratory

Professor:Taiji Adachi, Tel & Fax: 075-751-4853, E-mail: adachi@infront.kyoto-u.ac.jp
Associate Professor :Yasuhiro Inoue, Tel & Fax: 075-751-4849, E-mail: inoue@infront.kyoto-u.ac.jp
Lecturer:
Kennedy O. Okeyo, Tel & Fax: 075-751-4119, E-mail: okeyo@infront.kyoto-u.ac.jp
Assistant Professor:Yoshitaka Kameo, Tel & Fax: 075-751-4130, E-mail: kameo@infront.kyoto-u.ac.jp
Lab Homepage:http://www.frontier.kyoto-u.ac.jp/bf05/index-e.html