Tsuneyo Mimori, M.D., Ph.D. Professor
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by a chronic polyarticular synovitis that leads to irreversible joint damage with disability. The department of the Control for Rheumatic Diseases was established in April 2011 and is dedicated to treatment, research and education on rheumatic diseases with arthritis. Our outpatient clinic (RA center) will provide cutting-edge treatments to achieve a clinical remission or cure of RA and propose educational programs for co-medicals and patients.
Research and Education
Our goal is to cure or to control the disease activity of rheumatic diseases such as rheumatoid arthritis (RA). We conduct clinical and basic researches based on our comprehensive cohort system and RA sample center. Ongoing clinical researches are as follows: 1) identification of factors that lead to early diagnosis and prognosis of RA, 2) role of environmental factors for the initiation of rheumatic diseases, 3) roles of operative treatments on disease activity and functional prognosis. The topics of our basic research are as follows: 1) modification of autoimmunity in patients with rheumatoid arthritis by TNF inhibitors, 2) development of RA treatment using stem cells, 3) roles of CD4 T cells in rheumatic diseases, 4) suppression of joint destruction by control of juxtaarticular osteoporosis, and more with the collaboration with relevant departments. Another important mission of our department is education of medical students, co-medicals, and patients via lectures and RA classes that lead to thorough understanding of the pathophysiology, care and treatments of rheumatic diseases.
Ultrasound of joints for diagnosis and evaluation of rheumatoid arthritis
Recent Publications1.Hamamoto Y, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Iwata T, Mimori T, Matsuda S. Serological and Progression Differences of Joint Destruction in the Wrist and the Feet in Rheumatoid Arthritis – A Cross-Sectional Cohort Study. PLoS One. 2015 ;10(8):e0136611.
2.Terao C, Yano K, Ikari K, Furu M, Yamakawa N, Yoshida S, Hashimoto M, Ito H, Fujii T, Ohmura K, Yurugi K, Miura Y, Maekawa T, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F. A main contribution of DRB1*04:05 among shared epitope and involvement of 57th DRB1 amino acid in association with joint destruction in ACPA(+) RA. Arthritis Rheumatol 2015 (in press).
3.Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Hamamoto Y, Mimori T, Akiyama H, Matsuda S. Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis. Osteoporosis International 2015 In Press.
4.Terao C, Yamakawa N, Yano K, Markusse I, Ikari K, Yoshida S, Furu M, Hashimoto M, Ito H, Fujii T, Ohmura K, Murakami K, Takahashi M, Hamaguchi M, Tabara Y, Taniguchi A, Momohara S, Raychaudhuri S, Allaart C, Yamanaka H, Mimori T. Matsuda F. Rheumatoid factor is associated with the distribution of hand joint destruction in rheumatoid arthritis. Arthritis and Rheumaology 2015. In Press
5.Hashimoto M, Yamazaki T, Hamaguchi M, Morimoto T, Yamori M, Asai K, Isobe Y, Furu M, Ito H, Fujii T, Terao C, Mori M, Matsuo T, Yoshitomi H, Yamamoto K, Yamamoto W, Bessho K, Mimori T. Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients. PLoS One. 2015;10:e0122121.
LaboratoryProfessor: Tsuneyo Mimori
Associate Professor: Masao Tanaka
Associate Professor: Hiromu Ito
Assistant Professor: Motomu Hashimoto
Assistant Professor: Koichi Murata
Assistant Professor: Kohei Nishitani
Researcher: Natsuki Yamamoto