Respiratory Care and Sleep Control Medicine

kao Kazuo Chin (Hwa Boo Jin), M.D., Ph.D. Professor

The Department of Respiratory Care and Sleep Control Medicine is a new department which was started on April 1, 2008. The purpose of the department is to investigate the blood gas levels which are essential to life. Researches in this department include 1) refractory acute respiratory failure, including acute respiratory distress syndrome, 2) sleep disordered breathing, which has a significant effect on non-communicable diseases (NCDs), and 3) sleep associated symptoms. From translational research, we hope to develop a new therapy for respiratory failure and sleep disordered breathing.

Research and Education

Based on pulmonary physiology such as the regulation of breathing while awake and asleep, gas exchange, and lung mechanics, the purpose of our department is to develop new therapies for respiratory failure and sleep disturbances. We teach how to manage acute or chronic respiratory failure by using oxygen, noninvasive ventilation (NIV) such as CPAP, NPPV and ASV, and IPPV (Figure 1). Recently, it has been shown that intermittent and/or sustained hypoxia (IH and/or SH), which are induced by sleep disordered breathing, have significant effects on morbidity and mortality through transcriptional factors such as NFκ-B and hypoxia inducible factor-1 (HIF-1). We will research the effects of IH and SH using molecular biology and new techniques (Figure 2), and investigate the pathophysiological effects of IH and SH on humans. Through such research we will determine the effects of IH and SH on refractory respiratory failure and NCDs. We hope to develop new machines and drugs which manage several refractory respiratory failures, including acute respiratory distress syndrome and pulmonary fibrosis.

r-072-e1 Figure 2

Recent Publications

1.Harada Y, Chihara Y, Azuma M, Murase K, Toyama Y, Yoshimura C, Oga T, Nakamura H, Mishima M, Chin K, and Japan Respiratory Failure Group. Obesity hypoventilation syndrome in Japan and independent determinants of arterial carbon dioxide levels. Respirology 2014; 19; 1233-1240.
2.Murase K, Tabara Y, Takahashi Y, Muro S, Yamada R, Setoh K, Kawaguchi T, Kadotani H, Kosugi S, Sekine A, Nakayama T, Mishima M, Chiba T, Chin K,  Matsuda F, on behalf of the Nagahama Study Group. Gastroesophageal reflux disease symptoms and dietary behaviors are significant correlates of short sleep duration in the general population: The Nagahama Study. Sleep 2014; 37:1809-1815.
3.Chihara Y, Chin K, Aritake K, Harada Y, Toyama Y, Murase K, Yoshimura C,Hitomi T, Oga T, Mishima M, Urade Y. A urine biomarker for severe OSA:  Lipocaline-Type prostaglandin D synthase. Eur Respir J 2013; 42:1563-74
4.Toyama Y, Chin K, Chihara Y, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakaya-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M. Association between sleep apnea, sleep duration and serum lipid profile in an urban male working population in Japan Chest 2013; 143:720-8.
5.Murase K, Chihara Y, Takahashi K, Okamoto S, Segawa H, Fukuda K, Tanaka K, Uemoto S, Mishima M, Chin K. The use of noninvasive ventilation for pediatric patients following liver transplantation: Decrease in the need for reintubation. Liver Transplantation 2012;18:1217-25

Laboratory

Particular Professor :Kazuo Chin
Specific Associate Professor :Toru Oga
Specific Assistant Professor :Morito Inouchi ・ Kiminobu Tanizawa
TEL :+81-75-751-3852
FAX :+81-75-751-3854
e-mail :kokyusui@kuhp.kyoto-u.ac.jp