Human Brain Research Center

Tadashi Isa, M.D., Ph.D.
Director (concurrent service) btn

Recent advances in the brain research make most of non-invasive brain imaging methods: MRI and MEG. Human Brain Research Center or HBRC has investigated brain functions and methodological issues. In 2015, HBRC introduced a 7 Tesla MRI system installed only around 50 sites in the world. Its static magnetic field strength is more than 2 times higher than current 3 Tesla that is the maximum allowed for the clinical use, and expected to provide higher data quality. In view of clinical applications, HBRC is exploring human brain structures and functions.

Research and Education

Current medical researches are conducted at various levels from gene, cell, tissue, organ and system. They have made tremendous advance; however, they do not necessarily directly contribute to medical practice currently. This holds true in the neurosciences, because there exist large differences in the structure and function of the brain among species. Human brain comprises the largest and most developed system, and its researches have indispensable roles in basic and clinical neuroscience.
HBRC is focused on the human brain and has been observing it non-invasively from outside. Researches are focused on not only basic functions, but also pathophysiology of different kinds of disorders so as to contribute to clinical diagnosis and therapy. With collaboration with clinical departments that are related to the brain function and neural diseases, HBRC contributes to graduate education and researches.


Non-invasive neuroimaging studies are conducted from basics to clinical applications, including usage of a 7T-MRI system.

Recent Publications

  1. Pas M, Nakamura K, Sawamoto N, Aso T, Fukuyama H. Stimulus-driven changes in the direction of neural priming during visual word recognition. Neuroimage. 2016 Jan 15;125:428-36.
  2. Votinov M, Aso T, Fukuyama H, Mima T. A neural mechanism of preference shifting under zero price condition. Front. Hum. Neurosci. 2016. 10:177.
  3. Ashizuka A, Mima T, Sawamoto N, Aso T, Oishi N, Sugihara G, Kawada R, Takahashi H, Murai T, Fukuyama H. Functional relevance of the precuneus in verbal politeness. Neurosci Res. 2015 Feb;91:48-56.
  4. Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T. Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke. Neurosci Res. 2015 Mar;92:29-38.
  5. Aso T, Fukuyama H. Functional heterogeneity in the default mode network edges. Brain Connect. 2015 May;5(4):203-13.

Human Brain Research Center

Director: Tadashi Isa, M.D., Ph.D.
Associate Professor: Tomohisa Okada, M.D., Ph.D.
Assistant Professor: Toshihiko Aso, M.D., Ph.D.
Assistant Professor: Koji Fujimoto, M.D., Ph.D.
Phone: +81-75-751-3695
FAX: +81-75-751-3202