Hironori Haga, M.D., Professor
Diagnostic pathology is a clinical application of traditional anatomic pathology, contributing to determination of treatment strategy and evaluation of effects of treatment. Our department started as Laboratory of Anatomic Pathology in 1980, and has long been recognized as a branch laboratory of investigative pathology and clinical pathology. It is now responsible for all histopathological diagnosis of surgical specimens and autopsies in University Hospital as well as education of systemic pathology for undergraduate students.
Research and EducationMost of our researches are clinically oriented, and our goal is to provide accurate and scientific diagnosis based on histology and cytology.
Current research fields include 1) transplant pathology, 2) lung cancer, and 3) mast cell disorders. In transplant pathology, antibody-mediated rejection of the liver allografts has been our main interest. For lung cancer, we demonstrated that new WHO classification is closely related to genetic changes and patients’ prognosis. We also clarified that CD158d, also known as NK cell-specific receptor, has several functions in mast cells.
Education for graduate students is combination of research and advanced training for diagnostic pathology. Subspecialty training for surgical pathology is encouraged in combination with basic investigative research and/or clinic-pathologic study using immunohistochemistry and in situ hybridization. For research, in-house pathology diagnosis database, image analysis using virtual microcopy, and tissue microarray technique are also available.
1：Fluorescence in situ hybridization detecting ROS1 gene rearrangements (left) and a lung cancer tissue microarray slide (right)
- Yamaguchi M, Kataoka TR, Shibayama T, Fukuda A, Nakazawa A, Minamiguchi S, Sakurai T, Miyagawa-Hayashino A, Yorifuji T, Kasahara M, Uemoto S, Haga H. Loss of Hep Par 1 immunoreactivity in the livers of patients with carbamoyl phosphate synthetase 1 deficiency. Pathol Int. 2016 (in press)
- Shibayama T, Okamoto T, Nakashima Y, Kato T, Sakurai T, Minamiguchi S, Kataoka TR, Shibuya S, Yoshizawa A, Toguchida J, Haga H. Screening of BCOR-CCNB3 sarcoma using immunohistochemistry for CCNB3: A clinicopathological report of three pediatric cases. Pathol Int. 2015;65:410-414.
- Ueshima C, Kataoka TR, Hirata M, Furuhata A, Suzuki E, Toi M, Tsuruyama T, Okayama Y, Haga H. The killer cell Ig-like receptor 2DL4 expression in human mast cells and its potential role in breast cancer invasion. Cancer Immunol Res. 2015;3:871-880.
- Yoshizawa A, Sumiyoshi S, Sonobe M, Kobayashi M, Uehara T, Fujimoto M, Tsuruyama T, Date H, Haga H. HER2 status in lung adenocarcinoma: a comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations. Lung Cancer. 2014;85:373-378.
- Sumiyoshi S, Yoshizawa A, Sonobe M, Kobayashi M, Sato M, Fujimoto M, Tsuruyama T, Date H, Haga H. Non-terminal respiratory unit type lung adenocarcinoma has three distinct subtypes and is associated with poor prognosis. Lung Cancer. 2014;84:281-288.
Diagnostic PathologyProfessor Hironori Haga
Associate professor Takaki Sakurai, Sachiko Minamiguchi
Lecturer Akihiko Yoshizawa, Tatsuki R Kataoka
Specific hospital Assistant Professor Yosuke Yamada