Susumu Miyamoto, M.D., Ph.D. Professor
As the advance of neuroscience, neurosurgery has developed into a division of neuroscience from the specialized field concerned with the diagnosis and treatment of disorders or injuries in the brain, spinal cord or peripheral nerves. Our department is characterized as high activity in clinical science, a faculty to develop innovative treatments based on neuroscience, and establishments of medical evidence for the management of nervous system and neurovascular disorders. We collaborate with basic research laboratories and apply its results into the clinical field. This scientific approach is of great advantage to the education system in neurosurgery.
Research and EducationIn clinical research, we play a major role in the nationwide clinical studies and have reported high quality evidences. In basic research, we investigate molecular mechanisms in intracranial aneurysms, arteriovenous malformation, moyamoya disease, arteriosclerosis, glioma, pediatric brain tumor, pituitary adenoma. We try to establish a novel immunotherapy for malignant brain tumor and methodology for human brain imaging with high-resolution 3-tesla MRI and magnetoencephalography (MEG) and intraoperative brain functional mapping and monitoring. In the neuronal regeneration laboratory, we challenge to establish the regeneration treatment for Parkinson disease and brain ischemia using ES cells and iPS cells. Robot-assisted rehabilitation is being developed using neuro-functional study.
The aim of our education system is to provide a neurosurgeon with high-level skill as well as makings of a leader in neurosurgical field. A trainee can rapidly acquires the skill necessary to microsurgery and endovascular treatment through plenty of clinical experience and skill training in the laboratory. Furthermore, there are opportunities to learn techniques of neuros urgical subspecialty in the related hospital, such as spine surgery, pediatric neurosurgery and endovascular surgery.
A: Maximum flow reduction (MFR) strategy for large thrombosed aneurysms. B: Oncolytic therapy with vaccinia virus: vaccinia virus (green) and actin filament (red). C: Induction of neuronal cells from ES cells.
Members of the department in 2016
- Miyamoto S, Yoshimoto T, Hashimoto N, Okada Y, Tsuji I, Tominaga T, Nakagawara J, Takahashi JC; JAM Trial Investigators. Effects of extracranial-intracranial bypass for patients with hemorrhagic moyamoya disease: results of the Japan Adult Moyamoya Trial. Stroke. 45(5):1415-21, 2014.
- Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S. Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. Human Brain Mapping. 35(9):4345-61, 2014
- Hirata, E., Yukinaga, H., Kamioka, Y., Arakawa, Y., Miyamoto, S., Okada, T., Sahai, E., Matsuda, M. In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family gtpases in glioblastoma cell invasion. Journal of Cell Science, 125 (4), pp. 858-868, 2012.
- Yoshida K, Kurosaki Y, Funaki T, Kikuchi T, Ishii A, Takahashi JC, Takagi Y, Yamagata S, Miyamoto S. Surgical dissection of the internal carotid artery under flow control by proximal vessel clamping reduces embolic infarcts during carotid endarterectomy. World Neurosurger. 82(1-2):e229-34, 2014.
- Doi D, Samata B, Katsukawa M, Kikuchi T, Morizane A, Ono Y, Sekiguchi K, Nakagawa M, Parmar M, Takahashi J. Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation. Stem Cell Reports. 6;2(3):337-50, 2014.
Department of neurosurgeryProfessor ： Susumu Miyamoto
Associate Professor ： Yasushi Takagi
Junior Associate Professor ： Kazumichi Yoshida, Akira Ishii
Junior Associate Professor (Special Appointment) ： Yoshiki Arakawa
Assistant Professor ：Takayuki Kikuchi, Yohei Takenobu, Takeshi Funaki, Yohei Mineharu, Katsuya Komatsu
Special Appointment Assistant Professor ： Masahiro Tanji, Yukihiro Yamao
TEL ： +81-75-751-3459
FAX ： +81-75-752-9501
e-mail ： miy＠kuhp.kyoto-u.ac.jp
URL ： http://neurosur.kuhp.kyoto-u.ac.jp/