Ryosuke Takahashi, M.D. Ph.D.Professor
Neurological disorders will cause serious social problems in the upcoming super-aging society. Nevertheless, in many of the disorders, even the pathogenic mechanisms still remain to be unraveled. Our mission is 1)to provide the best quality care to patients, 2)to bridge the gap between bedside and neuroscience to develop better ways to diagnose, treat and prevent neurodegenerative diseases including Parkinson disease and amyotrophic lateral sclerosis (ALS), dementia such as Alzheimer disease and intractable epilepsy and 3)to educate medical students, residents and research fellows to raise leaders for the next generation.
Research and EducationOur department has 3 principal research fields.
The activities in neuropathology section can be divided into human neuropathology investigating autopsied brain and experimental neuropathology examining disease-model animal. Recently, we also apply in vivo imaging techniques to visualize pathological process in neurodegenerative diseases and dementias in the living brain.
In molecular neuroscience section, various novel cell and animal models of neurodegenerative diseases have been established to test hypotheses. We discovered that the accumulation of misfolded proteins can be a common mechanism leading to familial Parkinson disease and ALS. By extending our findings, we are trying to elucidate the enigmatic pathogenesis of the sporadic cases.
In clinical neurophysiology section, cortical control mechanism and its pathyphyisiology have been investigated based on the concept of system neuroscience. We evaluate epileptogenicity in human using electrophysiology and imaging techniques. Language function and its network are investigated by direct cortical stimulation and cortico-cortical evoked potentials.
Our department offers postgraduate clinical training for residents and hands-on training for undergraduate students studying medicine.
Neurology, faculty, fellows and residents 2012
Genetic interaction between PINK1 and Miro in DA neurons
Recent Publications1.PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R. Hum Mol Genet. 2013 in press.
2.Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R. J Biol Chem. 2012;287:42984-94.
3.Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation. Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, Fujita K, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, Kaji R, Takahashi R, Kawakami H. Acta Neuropathol. 2011;122:223-9.
4.Ictal wideband ECoG: Direct comparison between ictal slow shifts and high frequency oscillations. Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A. Clin Neurophysiol. 2011;122:1500-4.
5.Parieto-frontal network in humans studied by cortico-cortical evoked potential. Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H, Luders HO. Hum Brain Mapp. 2012;33:2856-72.
NeurologyProfessor: Ryosuke Takahashi
Associate Professor: Akio Ikeda
Senior Lecturer： Riki Matsumoto
Assistant Professor: Kengo Uemura, Nobukatsu Sawamoto, Hirofumi Yamashita, Hodaka Yamakado, Akihiro Kitamura