Otolaryngology-Head and Neck Surgery

大森先生顔写真 Koichi Omori, M.D., Ph.D. Professor btn

Otolaryngology – Head and Neck Surgery covers widespread diseases. Disorders of sensory organs (auditory, vestibular, olfactory, gustatory) are characteristic of our specialty. The most important research theme is deafness due to cochlear damages. We are mainly working on this project using regenerative medicine. Other projects are regeneration of mastoid mucosa, vocal fold, trachea, etc. Clinical application is now available for regeneration of inner ear using drug delivery system and for regeneration of ear drum and atrophied vocal folds. Researches on central auditory system are also performed using functional brain imaging.

Research and Education

■ Research Group for Inner Ear
Many people are bothered by sensorineural hearing loss and equilibrium disorders, most of which are caused by inner ear damage. However, no effective treatment exists for these symptoms because inner ear never regenerates once damaged after birth.
Our group aims to achieve functional regeneration of inner ears using several approaches; the application of IGF1 to sensorineural hearing loss 1), 2), highly efficient induction of iPS cells into inner ear hair cells, and comprehensive gene expression analysis using single cells from inner ears.

Protection of hair cells from aminoglycoside by Netrin1  [2]

■ Research Group for Head and Neck Regeneration

Tissue defects following trauma or cancer treatments in head and neck result in deterioration of QOL (quality of life) in patients. We have been trying to regenerate the larynx and the trachea using the in situ tissue engineering techniques.

①Regeneration / reconstruction of the trachea
We have developed an artificial trachea composed of polypropylene and collagen. For the better and safer tracheal reconstruction, recently we are investigating effectiveness and efficiency of the artificial trachea implantations combined with cells or growth factors.

Regenerated cartilaginous tissue in the bioengineered trachea (arrows). [3]

②Regeneration of the larynx
Novel therapeutic strategies using the regulation factors, scaffolding materials and variety of cells have been tried to regenerate the larynx.

Glottic regeneration using a decellularized porcine urinary bladder.[4]

医局集合写真Members of the departmant

Recent Publications

  1. Nakagawa T., Yamamoto M., Kumakawa K., et al.: Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study. Auris Nasus Larynx 43(5): 489-494, 2016.
  2. Yamahara K., Nakagawa T., Ito J., et al.: Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells. Neuropharmacology 119: 26-39, 2017.
  3. Nomoto M, Nomoto Y, Tada Y, et al.: Bioengineered trachea using autologous chondrocytes for regeneration of tracheal cartilage in a rabbit model. The Laryngoscope 123:2195–2201, 2013.
  4. Kitamura M, Hirano S, Kanemaru S-I, et al.: Glottic regeneration with a tissue-engineering technique, using acellular extracellular matrix scaffold in a canine model. J Tissue Eng Regen Med 10(10): 825-832, 2016.

Otolaryngology-Head and Neck Surgery

Professor: Koichi Omori
Senior Lecturer: Takayuki Nakagawa, Ichiro Tateya, Norio Yamamoto, Morimasa Kitamura
Assistant Professor: Masaru Yamashita, Takayuki Okano, Atsushi Suehiro, Yo Kishimoto, Takehiro Iki, Tomoko Kita, Hiroe Ohnishi
TEL: +81-75-751-3346
FAX: +81-75-751-7225
e-mail :inq@ent.kuhp.kyoto-u.ac.jp
URL :http://www.kuhp.kyoto-u.ac.jp/~ent/