Koichi Omori, M.D., Ph.D. Professor
Otolaryngology – Head and Neck Surgery covers widespread diseases. Disorders of sensory organs (auditory, vestibular, olfactory, gustatory) and aero digestive organs (respiration, swallowing, speech) are characteristic of our specialty for communication and life-sustaining function. We are working on projects of regenerative medicine for inner ear sensory cell and ear drum using drug delivery system. For laryngotracheal regeneration, artificial trachea was developed. Since 2017, we have conducted investigator initiated clinical trial of artificial trachea for practical application. Regeneration of airway cilial cell and tissue from iPS cell is also in progress.
Research and Education■ Research Group for Inner Ear
Many people are bothered by sensorineural hearing loss and equilibrium disorders, most of which are caused by inner ear damage. However, no effective treatment exists for these symptoms because inner ear never regenerates once damaged after birth.
Our group aims to achieve functional regeneration of inner ears using several approaches; the application of IGF1 to sensorineural hearing loss 1), 2), highly efficient induction of iPS cells into inner ear hair cells, and comprehensive gene expression analysis using single cells from inner ears.
Protection of hair cells from aminoglycoside by Netrin1 ■ Research Group for Head and Neck
Tissue defects following trauma or cancer treatments in head and neck result in deterioration of QOL in patients. We have been trying to regenerate the larynx and the trachea using in situ tissue engineering techniques.
Investigator initiated clinical trial of artificial trachea has been conducted since 2017. Cilial function and planar cell polarity of tracheal epithelium are analyzed3).
3D printing technology has been utilized for regeneration of the laryngeal tissue. Mechanism of tissue repair of the vocal fold epithelium is also analyzed4).
Artificial Trachea composed of polypropylene and collagen sponge
- Miyoshi T, Yamaguchi T, Ogita K, Tanaka Y, Ishibashi KI, Ito H, Kobayashi T, Nakagawa T, Ito J, Omori K, Yamamoto N.: Quantitative Analysis of Aquaporin Expression Levels during the Development and Maturation of the Inner Ear. J Assoc Res Otolaryngol. 2017 Apr;18(2):247-261.
- Yamahara K., Nakagawa T., Ito J., et al.: Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells. Neuropharmacology 119: 26-39, 2017.
- Tsuji T, Nakamura R, Katsuno T, Kishimoto Y, Suehiro A, Yamashita M, Uozumi R, Nakamura T, Tateya I, Omori K : Long-term preservation of planar cell polarity in reversed tracheal epithelium. Respir Res. 2018 Feb 2;19(1):22
- Suzuki R, Katsuno T, Kishimoto Y, Nakamura R, Mizuta M, Suehiro A, Yamashita M, Nakamura T, Tateya I, Omori K.: Process of tight junction recovery in the injured vocal fold epithelium: Morphological and paracellular permeability analysis. Laryngoscope. 2018 Apr;128(4)
Otolaryngology-Head and Neck SurgeryProfessor: Koichi Omori
Senior Lecturer: Takayuki Nakagawa, Ichiro Tateya, Norio Yamamoto, Morimasa Kitamura
Assistant Professor: Takayuki Okano, Atsushi Suehiro, Masahiro Kikuchi, Yo Kishimoto, Tomoko Tateya