Yoshiharu Sakai, M.D., Ph.D. Professor
Our division has an international reputation for its surgical expertise, especially for minimal invasive (endoscopic / robotic) approach to gastrointestinal malignancies; esophageal, gastric, colorectal carcinomas and gastrointestinal stromal tumor (GIST). We also target benign diseases such as inflammatory bowel diseases and achalasia. Our goal is to offer the finest-quality endoscopic/robotic surgeries for the benefit of patients, based on the rigorous surgical training, as well as multi-disciplinary treatment integrating knowledge from sturdy basic surgical research.
Research and EducationMajor research interests are as follows; 1) molecular biological analysis of gastrointestinal carcinomas including stem cell biology, 2) physiological assessment of postoperative gastrointestinal function, 3) development of new imaging system to unveil and understand more detailed surgical anatomy, 4) development of novel surgical procedures and surgical instruments, 5) active involvement in the multi-institutional clinical trials to evaluate outcome of the surgical treatments.
Endoscopic operations have provided the clear, magnified view even in the narrowest of the human body space and contributed to disclose the surgical anatomy. The precise recognition of surgical anatomy is absolutely mandatory to perform radical operations for cancers, avoiding neural damages and preserving functions. In addition, firm basic research will provide a scientific rationale for surgical therapy. A new surgical therapy must be further evaluated in well-designed clinical studies.
It is critical for surgical trainees to study surgical science as well as to obtain a good skill. We are confident that our program provides both of these in the finest quality.
- Metabolic alterations caused by KRAS mutations in colorectal cancer contribute to cell adaptation to glutamine-depletion by upregulation of asparagine synthetase. Neoplasia. (2016)
- Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis. Clin Cancer Res (2016)
- PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal denocarcinoma. Gastric Cancer (2016)
- Impact of hospital volume on risk-adjusted mortality following oesophagectomy in Japan.Br J Surg (2016)
- The Role of Periodic Serum CA19-9 Test in Surveillance After Colorectal Cancer Surgery. Int J Clin Oncol (2016)
Gastrointestinal SurgeryProfessor: Yoshiharu Sakai
Associate Professor: Kazutaka Obama
Senior Lecturer: Kenji Kawada, Shigeru Tsunoda, Koya Hida
Assistant Professor: Shigeo Hisamori, Susumu Inamoto, Yoshiro Itatani, Rei Mizuno