Clinical Laboratory Medicine


Emerging and re-emerging infectious diseases and increasing drug resistance in various pathogenic microorganisms have created a worldwide interest in infectious diseases. A complex failure in the balance between pathogen, host, and environment causes infectious diseases. While it is thus very important to establish a correct diagnosis and to administer appropriate treatment for infectious diseases, it is also very difficult. Our aims are to develop novel diagnostic methodologies and to identify clinical evidence that will lead to more efficient management of infectious diseases. Our mission is to develop young, promising clinicians and investigators who will take an active part internationally in the fields of clinical infectious diseases, infection epidemiology, and clinical microbiology.

Research and Education

Infection is caused by a variety of pathogens from a virion to a multicellular parasite, while infected hosts show a range of immunological status from completely healthy to severely immunocompromised. Many modalities such as microscopical examination, culturing, direct detection of antigens or genomes, are now available for the identification of causative pathogens leading to the initiation of optimal treatment. However, the correct cause cannot always be accurately identified, so that there is a growing need for the development and practical application of new technologies. To meet this need, we are cooperating with the clinical laboratory of Kyoto University Hospital and with many industries for the development and practical use of novel diagnostic methods for infectious diseases.
Infections in patients who are immunocompromised or have undergone aggressive surgery are likely to be highly complicating and life threatening. Effective prevention and control of nosocomial infections can be expected to result not only in improved outcomes but also in reduced medical costs. We are therefore conducting research into a thorough surveillance of postoperative or post-transplantation infections as well as into the prevention and control of these infections.
Unfortunately, the resources for adequate education in and management of infectious diseases in Japan have been insufficient compared with those available in other developed countries. To improve this situation, scientific rationality, rather than unsubstantiated “authoritative” comments, must take priority for better practice with regard to infectious diseases. At Kyoto University Hospital, we have been providing a sophisticated consultation service regarding efficient diagnostic procedures and appropriate management of patients with severe infection, which has resulted in a steady improvement of the prognosis for patients with nosocomial sepsis. In addition, we are educating both medical students and residents in the management of patients with infectious diseases on the basis of up-to-date clinical evidence.
We are continuing to pursue the development and application of novel methods for the diagnosis of infectious diseases, the control as well as prevention of nosocomial infection with the aim of putting everyday medical practice regarding infectious diseases on a foundation of scientific rationality.

r-044-1Left)The intervention by infectious diseases physicians in cases with Staphylococcus aureus bacteremia significantly reduced the 30-days mortality.
Right)We showed that both quantitative real-time PCR and blood (1→3)-β-D-glucan assays had high accuracy for discriminating colonization from microscopy-positive and -negative Pneumocystis pneumonia.

Recent Publications

  1. Population structure of Japanese extraintestinal pathogenic Escherichia coli and its relationship with antimicrobial resistance. Matsumura Y, Noguchi T, Tanaka M, Kanahashi T, Yamamoto M, Nagao M, Takakura S, Ichiyama S; 89th JAID BRG.. J Antimicrob Chemother. 2017 Apr 1;72(4):1040-1049. doi: 10.1093/jac/dkw530.
  2. Clinical and microbiologic characteristics of cefotaxime-non-susceptible Enterobacteriaceae bacteremia: a case control study. Noguchi T, Matsumura Y, Yamamoto M, Nagao M, Takakura S, Ichiyama S. BMC Infect Dis. 2017 Jan 7;17(1):44. doi: 10.1186/s12879-016-2150-6.
  3. Global Escherichia coli Sequence Type 131 Clade with blaCTX-M-27 Matsumura Y, Pitout JD, Gomi R, Matsuda T, Noguchi T, Yamamoto M, Peirano G, DeVinney R, Bradford PA, Motyl MR, Tanaka M, Nagao M, Takakura S, Ichiyama S. Emerg Infect Dis. 2016 Nov;22(11):1900-1907. doi: 10.3201/eid2211.160519.
  4. Interspecies Dissemination of a Mobilizable Plasmid Harboring blaIMP-19 and the Possibility of Horizontal Gene Transfer in a Single Patient. Yamamoto M, Matsumura Y, Gomi R, Matsuda T, Tanaka M, Nagao M, Takakura S, Uemoto S, Ichiyama S. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5412-9. doi: 10.1128/AAC.00933-16. Print 2016 Sep.
  5. Serotypes, antimicrobial susceptibility, and molecular epidemiology of invasive and non-invasive Streptococcus pneumoniae isolates in paediatric patients after the introduction of 13-valent conjugate vaccine in a nationwide surveillance study conducted in Japan in 2012-2014. Nakano S, Fujisawa T, Ito Y, Chang B, Suga S, Noguchi T, Yamamoto M, Matsumura Y, Nagao M, Takakura S, Ohnishi M, Ihara T, Ichiyama S. Vaccine. 2016 Jan 2;34(1):67-76. doi: 10.1016/j.vaccine.2015.11.015. Epub 2015 Nov 19.

Clinical Laboratory Medicine

Professor : Miki Nagao
Senior Lecturer : Yasufumi Matsumura, Takefumi Hitomi
Assistant Professor : Masaki Yamamoto, Yasuhiro Nakashima, Satoshi Nakano
TEL : +81-75-751-3502
FAX : +81-75-751-3233
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