Takashi Mizowaki, M.D., Ph.D. Professor
We are developing innovative radiotherapy technology to eradicate cancers. In molecular biological research, we are investigating causes for radioresistances and developing methods to overcome them through the analyses of DNA, RNA, proteins, etc. in experimental samples and clinical human cancer samples. In physical engineering research, we are driving forward high-precision radiotherapy such as intensity-modulated radiotherapy(IMRT), stereotactic radiotherapy and four-dimensional radiotherapy. We welcome the participation of physicians, biologists, and physical engineers who are interested in these translational approaches for cancer therapy.
Research and Education■ Biological approach
We are promoting a wide range of basic research. Specifically, development of new radiosensitizers, omics analysis of genomes, modeling of cell dynamics after irradiation with deep learning. We collaborate with the Laboratory of Cancer Cell Biology of Kyoto University for research of mechanism of cancer cells in the field of microbiology and the Institute for Integrated Radiation and Nuclear Science for basic research of boron neutron capture therapy (BNCT).
■ Physical engineering approach
We are developing high-precision radiotherapy and innovative beam delivery technique including dynamic tumor-tracking and Dynamic WaveArc irradiation as well as their treatment plans and quality control. Our final goal is to perform personalized radiotherapy based on the molecular tracking radiotherapy which fuses biological approaches to physical techniques.
■ Clinical research
We aim to apply results from the radiobiological and physical researches to clinical practice. We are conducting clinical trials on multidisciplinary treatment which combines high-precision radiotherapy with surgery/chemotherapy. Systemic organs can be our target: brain, lung, breast, esophagus, pancreas, prostate, rectum, anal canal, etc.
Neutrophil extracellular traps (NETs, shown in green) triggered by intravascular redox imbalance entrap circulating tumor cells (shown in red) at the lungs and promote pulmonary metastasis.
Dynamic tracking irradiation with (Vero4DRT) high precision image-guided radiation therapy device, which was developed in conjunction
- Hirashima H, Nakamura M, Miyabe Y, Uto M, Nakamura K, Mizowaki T. Monitoring of mechanical errors and their dosimetric impact throughout the course of non-coplanar continuous volumetric-modulated arc therapy. Radiation Oncology, 13, 27, 2018.
- Ono T, Miyabe Y, Takahashi K, Akimoto M, Mukumoto N, Ishihara Y, Nakamura M, Mizowaki T, Hiraoka M. Geometric and dosimetric accuracy of dynamic tumor tracking during volumetric-modulated arc therapy using a gimbal mounted linac. Radiother Oncol., 129, 166-172, 2018.
- Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Torii M, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha. Nature Communications, 6, 6153, 2015.
- Iizuka Y, Matsuo Y, Ishihara Y, Akimoto M, Tanabe H, Takayama K, Ueki N, Yokota K, Mizowaki T, Kokubo M, Hiraoka M. Dynamic tumor-tracking radiotherapy with real-time monitoring for liver tumors using a gimbal mounted linac. Radiotherapy and Oncology, 117, 496-500, 2015.
- Matsuo Y, Ueki N, Takayama K, Nakamura M, Miyabe Y, Ishihara Y, Mukumoto N, Yano S, Tanabe H, Kaneko S, Mizowaki T, Monzen H, Sawada A, Kokubo M, Hiraoka M. Evaluation of dynamic tumour tracking radiotherapy with real-time monitoring for lung tumours using a gimbal mounted linac. Radiotherapy and Oncology, 112, 360-364, 2014.
Radiation Oncology and Image-Applied TherapyProfessor：Takashi Mizowaki
Associate Professor：Yukinori Matsuo
Senior Lecturer：Michio Yoshimura
Program-Specific Senior Lecturer：Yuki Miyabe
Assistant professor： Katsuyuki Sakanaka・Aya Nakajima・Minoru Inoue・Yusuke Iizuka
Program-Specific Assistant professor：Megumi Uto・Kiyonao Nakamura・Nobutaka Mukumoto・Tomohiro Ono・Hiraku Iramina