Takashi Mizowaki, M.D., Ph.D. Professor
We are developing innovative treatment approaches to eradicate cancers. As molecular biological approaches, we are investigating how cancer cells acquire radioresistance and capability of metastasis through the analyses of DNA, RNA, and protein in diagnostic human cancer samples as well as in experimental models. As physics engineering approaches, we are driving forward high-precision radiotherapy such as intensity-modulated radiotherapy, stereotactic irradiation and 4-D radiotherapy. Physicians, biologists, and experts in physics engineering who are interested in these translational approaches for cancer therapy are welcome.
Research and Education■ Biological approach
Our research is focused on the translational radiation medicine between basic science and radiation therapies for cancer patients. Based on the multidisciplinary input of the pathophysiology of human cancer, we are investigating the unknown role of redox homeostasis, immune cells, and tumor hypoxia in anti-tumor effect of radiation. Our ultimate goal is to identify new therapeutic targets which worth testing in clinical trials. We collaborate with the Institute for Integrated Radiation and Nuclear Science for basic research of BNCT and with the Laboratory of Cancer Cell Biology of Kyoto University.
■ Physics and engineering approach
We are implementing basic researches and clinical applications of advanced high-precision radiotherapy and innovative beam delivery technique including dynamic tumor-tracking and Dynamic WaveArc irradiation. Our final goal is to achieve molecular tracking radiotherapy which integrates biological approaches into physics and engineering approaches.
■ Clinical research
We aim to apply results from the radiobiological and medical physics researches to clinical practice. We are conducting clinical trials on multidisciplinary treatment which combines high-precision radiotherapy with surgery and/or chemotherapy. All organs can be our target: metastatic brain tumor, lung cancer, breast cancer, esophageal cancer, pancreas cancer, prostate cancer, rectal cancer, etc.
Neutrophil extracellular traps (NETs, shown in green) triggered by intravascular redox imbalance entrap circulating tumor cells (shown in red) at the lungs and promote pulmonary metastasis.
Dynamic tracking irradiation with (Vero4DRT) high precision image-guided radiation therapy device, which was developed in conjunction
- Hirashima H, Nakamura M, Miyabe Y, Uto M, Nakamura K, Mizowaki T. Monitoring of mechanical errors and their dosimetric impact throughout the course of non-coplanar continuous volumetric-modulated arc therapy. Radiation Oncology, 13, 27, 2018.
- Ono T, Miyabe Y, Takahashi K, Akimoto M, Mukumoto N, Ishihara Y, Nakamura M, Mizowaki T, Hiraoka M. Geometric and dosimetric accuracy of dynamic tumor tracking during volumetric-modulated arc therapy using a gimbal mounted linac. Radiother Oncol., in press, 2017.
- Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Torii M, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha. Nature Communications, 6, 6153, 2015.
- Iizuka Y, Matsuo Y, Ishihara Y, Akimoto M, Tanabe H, Takayama K, Ueki N, Yokota K, Mizowaki T, Kokubo M, Hiraoka M. Dynamic tumor-tracking radiotherapy with real-time monitoring for liver tumors using a gimbal mounted linac. Radiotherapy and Oncology, 117, 496-500, 2015.
- Matsuo Y, Ueki N, Takayama K, Nakamura M, Miyabe Y, Ishihara Y, Mukumoto N, Yano S, Tanabe H, Kaneko S, Mizowaki T, Monzen H, Sawada A, Kokubo M, Hiraoka M. Evaluation of dynamic tumour tracking radiotherapy with real-time monitoring for lung tumours using a gimbal mounted linac. Radiotherapy and Oncology, 112, 360-364, 2014.
Radiation Oncology and Image-Applied TherapyProfessor：Takashi Mizowaki
Associate Professor：Yukinori Matsuo
Senior Lecturer：Michio Yoshimura
Program-Specific Senior Lecturer：Yuki Miyabe
Assistant professor：Kenji Takayama・Katsuyuki Sakanaka・Aya Nakajima・Minoru Inoue
Program-Specific Assistant professor：Yusuke Iizuka・Megumi Uto・Nobutaka Mukumoto・Tomohiro Ono・Hiraku Iramina