Pediatrics

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The most important thing in the Pediatrics is “development”. A number of pediatric diseases are derived from the disorders during developmental process. Therefore, investigations on them should lead to the exploitation of new diagnosis and treatment for intractable diseases. By imposing close relationship between clinic and laboratory on our research, we would like to apply our outcomes obtained from clinic and laboratory to children with intractable diseases.

Research and Education

As a clinical department, further developing translational research is the most important mission in order to provide optimized and high-quality medicine for patients. Therefore, to elucidate molecular mechanisms and develop new therapeutic strategies of intractable pediatric diseases, we currently perform multi-omics analysis using genetic and epigenetic approaches. In addition, we also apply human iPS cell technology to get a better understanding of etiologies of congenital diseases and establish regenerative medicine for patients with intractable diseases. Our research projects are aiming to contribute to the development of pediatric research as well as life science. We will continue to foster and inspire excellent physician scientists who devote their professional effort seeking new knowledge about basic research to care patients.

Discovery of novel SPI1 fusions in pediatric T cell acute lymphoblastic leukemia

Recent Publications
  1. Kato I, Nishinaka Y, Nakamura M, Akarca AU, Niwa A, Ozawa H, Yoshida K, Mori M, Wang D, Morita M, Ueno H, Shiozawa Y, Shiraishi Y, Miyano S, Gupta R, Umeda K, Watanabe K, Koh K, Adachi S, Heike T, Saito MK, Sanada M, Ogawa S, Marafioti T, Watanabe A, Nakahata T, Enver T. Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGF. Blood. 129(23):3126-3129, 2017.
  2. Yoshida T, Awaya T, Jonouchi T, Kimura R, Kimura S, Era T, Heike T, Sakurai H.  A Skeletal Muscle Model of Infantile-onset Pompe Disease with Patient-specific iPS Cells. Sci Rep. 7(1):13473, 2017.
  3. Iwanaga K, Yamamoto A, Matsukura T, Niwa F, Kawai M. Corticotrophin-releasing hormone stimulation tests for the infants with relative adrenal insufficiency. Clin Endocrinol. 87:660-664, 2017.
  4. Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, Wang C, Lin L, Kon A, Suzuki H, Shiozawa Y, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J. Recurrent PU.1 (SPI1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nat Genet. 49(8):1274-1281, 2017.
  5. Shibata H, Yasumi T, Shimodera S, Hiejima E, Izawa K, Kawai T, Shirakawa R, Wada T, Nishikomori R, Horiuchi H, Ohara O, Ishii E, Heike T. Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis. Blood. 131(18): 2016-2025, 2018.

Pediatrics

Professor: Junko Takita
Associate Professor: Masahiko Kawai, Takahiro Yasumi
Senioir Lecture: Hidefumi Hiramatsu
Assistant Professor: Katsutsugu Umeda, Fusako Niwa, Siro Baba, Takuya Hirata, Atsushi Yokoyama, Kazushi Izawa, Kogoro Iwanaga, Itaru Kato, Takeshi Yoshida, Satoshi Saida,Seiichi Tomotaki
TEL: +81-75-751-3290
FAX: +81-75-752-2361
e-mail: shonika@kuhp.kyoto-u.ac.jp
URL: http://www.kuhp.kyoto-u.ac.jp/~pediatrics/