Therapeutic Oncology

kao Manabu Muto, M.D., Ph.D., Professor btn

This department was founded in September 2012 as the main department of the “Kyoto University Hospital Cancer Center” established in 2007 for the first time among national and public universities. We support the functional management of the Cancer Center in the academia and promote the following: 1) specialized and cutting-edge oncology practice and education. 2) practice of clinical research and education, 3) basic oncology research, 4) translational oncology applying basic research for clinical practice, and 5) cancer bio-bank projects leading to development of the next-generation medical care.

Research and Education

In this course, cancer research has been advanced from elucidating carcinogenic mechanisms to developing early diagnostic methods, new treatment, supportive treatment to improve QOL, and clinical application of genomic medicine. The course is particularly aimed at elucidating the molecular-level carcinogenic mechanism of esophageal squamous cell carcinoma by alcohol and developing preventive methods. New diagnostic methods using exhaled breath and near-infrared light have been developed. New concepts-based curative cancer treatment has been developed in investigator-initiated trials. Supportive treatment to prevent organ injury by anticancer drugs and chemotherapy for patients with organ dysfunction (e.g., renal dysfunction) have been developed with other departments (e.g., Nephrology, Pharmacology). Furthermore, translational researches contributing to the early approval of seeds developed by basis research departments have been projected, while clinical studies utilizing the National Database (NDB) have been advanced with social medicine courses as well as medical information sections. Graduate school students and junior residents can select suitable fields and receive specialized education. Moreover, graduate school students in “the training course to be specialized researchers who develop next-generation anticancer drugs” in the cancer professional training basic arrangement plan have actively been accepted.

Research on acetaldehyde-mediated esophageal carcinogenesis

Functional analysis of genetic variation identified by clinical sequence


Recent Publications

  1. Tomohiro Kondo, Masashi Kanai, Tadayuki Kou, Tomohiro Sakuma, Hiroaki Mochizuki, Mayumi Kamada, Masahiko Nakatsui, Norimitsu Uza, Yuzo Kodama,Toshihiko Masui, Kyoichi Takaori, Shigemi Matsumoto, Hidehiko Miyake, Yasushi Okuno and Manabu Muto. Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer. Oncotarget. 2018; 9:19817-19825.
  2. Taro Funakoshi, Takahiro Horimatsu, Michio Nakamura, Koichi Shiroshita, Koichi Suyama, Masashi Mukoyama, Takuro Mizukami, Tsutomu Sakurada, Eishi Baba, Kazuhiko Tsuruya, Akira Nozaki, Kensei Yahata, Yukinori Ozaki, Yoshifumi Ubara, Hisateru Yasui, Akihiro Yoshimoto, Shingo Fukuma, Naoya Kondo, Takeshi Matsubara, Kazuo Matsubara, Shunichi Fukuhara, Motoko Yanagita, Manabu Muto. Chemotherapy in cancer patients undergoing hemodialysis: A nationwide study in Japan ESMO Open 2018 Feb 23;3(2):e000301.
  3. Yasumasa Ezoe, Junki Mizusawa, Hiroshi Katayama, Kozo Kataoka, Manabu Muto. An integrated analysis of hyponatremia in cancer patients receiving platinum-based or nonplatinum-based chemotherapy in clinical trials (JCOG1405-A) Oncotarget 2018; 9:6595-6606.
  4. Mizumoto A, Ohashi S, Hirohashi K, Amanuma Y, Matsuda T, Muto M. Molecular mecanisms of acetaldehyde-mediated carcinogenesis in squamous epithelium. Int J Mol Sci 2017; 18(9). E1943.
  5. Yoshioka M, Ohashi S, Muto M, et al. Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma. J Exp Clin Cancer Res 2017; 36(1): 101.

Therapeutic Oncology

Professor: Manabu Muto
Associate Professor: Shigemi Matsumoto
Program-Specific Associate Professor: Masashi Kanai
Program-Specific Lecturer: Atsushi Yamada
Assistant Professor: Shinya Ohashi, Takahiro Horimatsu
Program-Specific Assistant Professor: Tadayuki Kou, Junichi Matsubara, Takashi Ura, Nobuko Kawaguchi, Yuichi Sakamori, Makiko Funakoshi, Akira Yokoyama
TEL : 075-751-4592
FAX : 075-751-4594
e-mail : oncology@kuhp.kyoto-u.ac.jp
URL : http://oncology.kuhp.kyoto-u.ac.jp