Motoko Yanagita, MD, PhD, Professor
Nephrology department has extensive programs in patient care, research, and education.
Our clinical mission is to provide the highest level of patient care in varieties of kidney diseases, utilizing the biggest dialysis unit among the national universities in Japan.
Our research goal is to understand the pathophysiology of kidney disease progression, and to propose novel effective therapeutic agents.
Our training program provides broad training in all the major areas of nephrology with opportunities to develop clinical and research skills, aiming to mentor clinical fellows to become physician scientists.
Research and educationOur basic research team aims to discover the reversibility of kidney diseases.
Current areas of research focus include studies of the mechanisms of fetal programming of predisposition to kidney diseases, identification of accelerating factors of kidney diseases, elucidation of the endogenous repair activities in the kidney, and analysis of the mechanisms of fibrosis and renal anemia.
Our clinical research programs encompass a range of important areas in the field of nephrology, such as the establishment of kidney injury surveillance system (KISS), quantitative pathology, and onco-nephrology, a new field linking oncology and nephrology. Special program is designed to focus on the standardization of the cancer treatment in patients with end-stage renal disease.
Our department is aiming to foster “physician scientists” who can solve their patient-oriented research questions by their own research skills.
- Yuki Sato, Akiko Mii, Yoko Hamazaki, Harumi Fujita, Hirosuke Nakata, Kyoko Masuda, Shingo Nishiyama, Shinsuke Shibuya, Hironori Haga, Osamu Ogawa, Akira Shimizu, Shuh Narumiya, Tsuneyasu Kaisho, Makoto Arita, Masashi Yanagisawa, Masayuki Miyasaka, Kumar Sharma, Nagahiro Minato, Hiroshi Kawamoto, Motoko Yanagita.
“Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney”
- Koji Takaori, Jin Nakamura, Shinya Yamamoto, Hirosuke Nakata, Yuki Sato, Masayuki Takase, Masaaki Nameta, Tadashi Yamamoto, Aris N. Economides, Kenji Kohno, Hironori Haga, Kumar Sharma, Motoko Yanagita.
“Severity and frequency of proximal tubule injury determines renal prognosis” J Am Soc Nephrol. 2016 Aug;27(8):2393-406.
- Tomomi Endo, Jin Nakamura, Yuki Sato, Misako Asada, Ryo Yamada, Masayuki Takase, Koji Takaori, Akiko Oguchi, Taku Iguchi, Atsuko Y. Higashi, Tetsuya Ohbayashi, Tomoyuki Nakamura, Eri Muso, Takeshi Kimura, and Motoko Yanagita.
“Exploring the origin and limitations of kidney regeneration” J Pathol. 2015 Jun;236(2):251-63.
- Nariaki Asada, Masayuki Takase, Jin Nakamura, Akiko Oguchi, Misako Asada, Norio Suzuki, Ken-ichi Yamamura, Narihito Nagoshi, Shinsuke Shibata, Tata Nageswara Rao, Hans Joerg Fehling, Atsushi Fukatsu, Naoko Minegishi, Toru Kita, Takeshi Kimura, Hideyuki Okano, Masayuki Yamamoto, and Motoko Yanagita.
“Dysfunction of fibroblasts of extra-renal origin underlies renal fibrosis and renal anemia in mice” J Clin Invest. 2011 Oct;121(10):3981-90.
- Mari Tanaka, Misako Asada, Atsuko Y Higashi, Jin Nakamura, Akiko Oguchi, Mayumi Tomita, Sachiko Yamada, Nariaki Asada, Masayuki Takase, Tomohiko Okuda, Hiroshi Kawachi, Aris N. Economides, Elizabeth Robertson, Satoru Takahashi, Takeshi Sakurai, Roel Goldschmeding, Eri Muso, Atsushi Fukatsu, Toru Kita, and Motoko Yanagita.
“Loss of the BMP antagonist, USAG-1 ameliorates disease in a mouse model of progressive hereditary kidney disease Alport syndrome” J Clin Invest. 2010 Mar;120(3):768-77.
Department of NephrologyProfessor：Motoko Yanagita
Senior Lecturer：Takeshi Matsubara
Senior Lecturer：Hideki Yokoi
Assistant Professor：Shuichiro Endo
Assistant Professor：Akira Ishii
Specific hospital Assistant Professor：Kaoru Sakai
Specific hospital Assistant Professor：Naoya Kondo
Specific hospital Assistant Professor：Naohiro Toda
Specific Assistant Professor：Yuki Sato