Nobuya Inagaki, M.D., Ph.D.
The Department of Diabetes, Endocrinology and Nutrition contributes to the advancement of diabetology, endocrinology, and nutrition science. Advanced basic research on diabetes and endocrine diseases is conducted using leading-edge technologies in order to better understand the various pathological conditions and to discover novel therapeutic approaches. We also take the initiative in promoting clinical research, epidemiological studies, and patient education for improved treatment outcomes. The nutritional approach is employed to address serious social matters such as obesity, metabolic syndrome, dementia, and frailty. Our diverse experience provides young medical doctors an opportunity to become internationally active researchers and highly trained physicians.
Research and Education
Our major interest is pathophysiology of metabolic diseases, especially diabetes mellitus and endocrine diseases, and nutrition. We are investigating 1) mechanism for insulin secretion, 2) mechanism of incretin secretion from enteroendocrine cells and incretin action in various organs, 3) metabolic regulation in liver, 4) generation of insulin-producing cells and vascular endothelium from iPS cells, 5) non-invasive β-cell imaging, 6) basic research for disorders in pituitary-adrenal system and bone metabolism, and 7) clinical research for diabetes, obesity, endocrine diseases, and nutrition. All of them could be helpful for the diagnosis and treatment of patients with the diseases.
We use molecular biological, biochemical, physiological, electrophysiological, cell biological methods and the most advanced analytical methods as well as genetically engineered mice. All the teaching staffs discuss with, advice, and encourage students and instruct the practical techniques required to carry out the experiments. During the course of the research, the student learns the numerous skills required for systematic analysis and scientific decision making.
Ⅰ.Research projects in diabetes and metabolic disorders
Ⅱ.Research projects in endocrine disorders and clinical nutrition
- Joo E et al., Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high-fat diet-fed mice. Diabetes. 66(4):868-879, 2017
- Kondo Y, et al., Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 60(8):1454-1466, 2017.
- Oguri Y et al., Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism. JCI Insight. 2(9), 2017
- Kanai Y, et al., Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance. J Clin Invest. 127(11):4136-4147, 2017
- Matsuo K, et al., Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells. Sci Rep. 7(1):15120, 2017
Diabetes, Endocrinology and NutritionProfessor: Nobuya Inagaki
Associate Professor: Hiroshi Kondo (Department of Community Network and Collaborative Medicine, Kyoto University Hospital)
Lecturer: Akihiro Yasoda, Norio Harada
Special Appointment Lecturer (Hospital): Junji Fujikura
Program-Specific Associate Professor: Masakatsu Sone, Daisuke Yabe
Assistant professor: Yoshihito Fujita, Daisuke Tanaka, Hisahito Fujii, Shunsuke Yamane, Hiroyuki Fujimoto (Radioisotope Research Center, Agency for Health, Safety and Environment, Kyoto University)
Special Appointment Assistant Professor (Hospital): Kaori Ikeda
Program-Specific Assistant Professor: Daisuke Taura, Masahito Ogura
TEL ： +81-75-751-3560
FAX ： +81-75-751-4244
e-mail ： firstname.lastname@example.org
URL ： http://metab-kyoto-u.jp/