Nobuya Inagaki, M.D., Ph.D.
The Department of Diabetes, Endocrinology and Nutrition contributes to the advancement of diabetology, endocrinology, and nutrition science. Advanced basic research on diabetes and endocrine diseases is conducted using leading-edge technologies in order to better understand the various pathological conditions and to discover novel therapeutic approaches. We also take the initiative in promoting clinical research, epidemiological studies, and patient education for improved treatment outcomes. The nutritional approach is employed to address serious social matters such as obesity, metabolic syndrome, dementia, and frailty. Our diverse experience provides young medical doctors an opportunity to become internationally active researchers and highly trained physicians.
Research and EducationOur major interest is pathophysiology of metabolic diseases, especially diabetes mellitus and endocrine diseases, and nutrition. We are investigating 1) mechanism for insulin secretion, 2) mechanism of incretin secretion from enteroendocrine cells and incretin action in various organs, 3) metabolic regulation in liver, 4) generation of insulin-producing cells and vascular endothelium from iPS cells, 5) non-invasive β-cell imaging, 6) basic research for disorders in pituitary-adrenal system and bone metabolism, and 7) clinical research for diabetes, obesity, endocrine diseases, and nutrition. All of them could be helpful for the diagnosis and treatment of patients with the diseases.
We use molecular biological, biochemical, physiological, electrophysiological, cell biological methods and the most advanced analytical methods as well as genetically engineered mice. All the teaching staffs discuss with, advice, and encourage students and instruct the practical techniques required to carry out the experiments. During the course of the research, the student learns the numerous skills required for systematic analysis and scientific decision making.
Recent Publications1.Inagaki N, et al. Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science. 270(5239):1166-70, 1995
2.Yoshihara E, et al. Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nat Commun. 1:127, 2010
3.Suzuki K, et al. Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity. J Biol Chem. 288(3):1929-38, 2013
4.Sasaki M, et al. Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction. Diabetes. 62(6):1996-2003, 2013
5.Nasteska D, et al. Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high fat diet condition. Diabetes. 63(7):2332-2343, 2014
Diabetes, Endocrinology and NutritionProfessor ：Nobuya Inagaki
Lecturer ： Kazuaki Nagashima・Akihiro Yasoda・Shinichi Harashima
Special Appointment Lecturer ：Masakatsu Sone
Special Appointment Lecturer (Hospital) ：Norio Harada・Junji Fujikura・Hiroshi Kondoh
Assistant professor ： Yoshihito Fujita・Daisuke Tanaka・Hisahito Fujii・Tutomu Tomita・
Shunsuke Yamane・Hiroyuki Fujimoto(Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital)
Special Appointment Assistant professor ： Masahito Ogura・Daisuke Taura・Kaori Ikeda
TEL ： +81-75-751-3560
FAX ： +81-75-751-4244
e-mail ： firstname.lastname@example.org
URL ： http://metab-kyoto-u.jp/