Nobuya Inagaki, M.D., Ph.D.
The Department of Diabetes, Endocrinology and Nutrition contributes to the advancement of diabetology, endocrinology, and nutrition science. Advanced basic research on diabetes and endocrine diseases is conducted using leading-edge technologies in order to better understand the various pathological conditions and to discover novel therapeutic approaches. We also take the initiative in promoting clinical research, epidemiological studies, and patient education for improved treatment outcomes. The nutritional approach is employed to address serious social matters such as obesity, metabolic syndrome, dementia, and frailty. Our diverse experience provides young medical doctors an opportunity to become highly trained physicians.
Research and Education
We are investigating 1) islet biology, 2) mechanism of incretin secretion from enteroendocrine cells and incretin action in various organs, 3) genetic investigation of young-onset and familial clustered diabetes, 4) novel therapeutic approaches to obesity and diabetes using brown adipose tissue, 5) generation of endocrine organs including insulin-producing cells and vascular endothelium from iPS cells, 6) non-invasive imaging of pancreatic β-cell and adrenal gland, 7) basic research for disorders in pituitary-adrenal system, thyroid gland and bone metabolism, and 8) clinical research for diabetes, obesity, endocrine diseases, and nutrition. The approach ranges from clinical to basic, and the research scale varies from pioneering small-scale study to large-scale research funded by Health and Labor Sciences Research Grant. All the teaching staffs discuss with, advice, and encourage students and instruct the practical techniques required to carry out the experiments. In addition, we work at upbringing of the experts in diabetology and endocrinology who can provide high quality treatment with a broad perspective that transcends any narrow specialization.
Ⅰ.Research projects in diabetes and metabolic disorders
Ⅱ.Research projects in endocrine disorders and clinical nutrition
- Jambaljav B, Tanaka D, Nagashima K, Harashima SI, Harada N, Fujiwara Y, Wang Y, Liu Y, Tabara Y, Matsuda F, Koizumi A, and Inagaki N. Whole-exome sequencing in a Japanese family with highly aggregated diabetes identifies a candidate susceptibility mutation in ADAMTSL3. Diabetes Res Clin Pract. 135:143-149, 2018.
- Ikeguchi E, Harada N, Kanemaru Y, Sankoda A, Yamane S, Iwasaki K, Imajo M, Murata Y, Suzuki K, Joo E, and Inagaki N. Transcriptional factor pancreatic duodenal homeobox-1 (Pdx1) is involved in age-related GIP hypersecretion in mice. Am. J. Physiol. Gastrointest Liver Physiol. 315(2):G272-G282, 2018.
- Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y, Kurihara I, Itoh H, Umakoshi H, Tsuiki M, Ichijo T, Katabami T, Tanaka Y, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Yoneda T, Hashimoto S, Yanase T, Suzuki T, Kawamura T, Tabara Y, Matsuda F, Naruse M; Nagahama Study; JPAS Study Group. Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan. Hypertension. 71(3):530-537,2018.
- Hirota K, Furuya M, Morozumi N, Yoshikiyo K, Yotsumoto T, Jindo T, Nakamura R, Murakami K, Ueda Y, Hanada T, Sade H, Yoshida S, Enomoto K, Kanai Y, Yamauchi I, Yamashita T, Ueda-Sakane Y, Fujii T, Yasoda A, Inagaki N. Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats. PLoS One. 13(9):e0204172, 2018.
- Hamamatsu K, Fujimoto H, Fujita N, Murakami T, Kimura H, Saji H, Inagaki N. Establishment of a method for in-vivo SPECT/CT imaging analysis of 111In-labeled exendin-4 pancreatic uptake in mice without the need for nephrectomy or a secondary probe. Nucl Med Biol. 64-65:22-27, 2018.
Diabetes, Endocrinology and NutritionProfessor: Nobuya Inagaki
Program-Specific Associate Professor: Masakatsu Sone
Lecturer: Norio Harada
Special Appointment Lecturer (Hospital): Junji Fujikura
Assistant professor: Yoshihito Fujita, Daisuke Tanaka, Hisahito Fujii,
Masahito Ogura, Shunsuke Yamane, Hiroyuki Fujimoto (Radioisotope Research Center, Agency for Health, Safety and Environment, Kyoto University) ,
Special Appointment Assistant Professor (Hospital): Kaori Ikeda, Ichiro Yamauchi
Program-Specific Assistant Professor: Daisuke Taura, Ryota Usui, Hisato Tatsuoka
Program-Specific Professor (Preemptive Medicine and Lifestyle. Disease Research Center): Mayumi Inoue
Program-Specific Assistant Professor (Preemptive Medicine and Lifestyle. Disease Research Center): Yoriko Sakane, Tomoko Kuwahara, Kazuyo Suzuki
TEL ： +81-75-751-3560
FAX ： +81-75-751-4244
e-mail ： firstname.lastname@example.org
URL ： http://metab-kyoto-u.jp/