Gastroenterology and Hepatology

Hiroshi Seno,M.D.,Ph.D.,Professor btn

Our department has been established in 1996. As a clinical department, our goal is to produce not only many good clinical specialists for gastroenterology who can understand both clinical medicine and basic science but also researchers for basic gastroenterology. As a clinical department, we cover all the field of gastroenterology, while in the research field we are particularly focusing on oncology, immunology and development and differentiation. Our final goal is to create new modalities for treatment of various gastroenterological diseases.

Research and Education

Period of residency is very important for young doctors to become good physicians. So, we are doing our best to educate young doctors to become general internists as well as specialists for gastroenterology. In particular, after finishing residency, we prepare a special course for training clinical gastroenterology. Our research projects cover liver diseases, pancreato-biliary diseases, and upper and lower gastrointestinal tract diseases. Particularly, we are focusing on cancers, immunological diseases such as inflammatory bowel disease, and regeneration of gastrointestinal organs. For recent years, we have clarified significance of occult infection of HBV in the development of liver cancer, roles of immunological responses to H. pylori in the development of various gastric diseases such as gastric cancer and MALT lymphoma, and mechanisms for inflammation-associated carcinogenesis, and identified a novel cancer stem cell marker. We have also developed a novel method for treating IBD. Moreover, we made significant contribution to establishing the concept of autoimmune pancreatitis. Now, we are working hard to establish treatment for various gastrointestinal cancers and IBD.

r-032-11.Lineage tracing in Dclk1-CreERT2; R26R; ApcMin mouse intestinal tumors:
We revealed that Dclk1 distinguishes between tumor and normal stem cells in the intestine.

SONY DSC2.Members of the laboratory.

Recent Publications

  1. Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, Azuma T, Okazaki IM, Honjo T, Chiba T: Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 13:470-476:2007.
  2. Tsuji Y, Watanabe T, Kudo M, Arai H, Strober W, Chiba T: Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis. Immunity 37:326-338:2012.
  3. Arasawa S, Nakase H, Ozaki Y, Uza N, Matsuura M, Chiba T: Mediterranean mimicker. Lancet 380:2052:2012.
  4. Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, Nakanishi N, Kanda K, Komekado H, Kawada M, Isomura A, Kawada K, Sakai Y, Yanagita M, Kageyama R, Kawaguchi Y, Taketo MM, Yonehara S, Chiba T: Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet 45:98-103:2013.
  5. Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T. Pathogenicity of IgG in patients with IgG4-related disease. Gut. 2016 65(8):1322-32.

Gastroenterology and Hepatology

Professor:Hiroshi Seno
Associate Professor:Hiroyuki Marusawa
Senior Lecturer:Yuzo Kodama
Assistant Professor:Shinichi Miyamoto, Minoru Matsuura, Norimitsu Uza,
Ken Takahashi, Akihisa Fukuda, Shuji Yamamoto
TEL : +81-75-751-4319
FAX : +81-75-751-4303