Cardiovascular Medicine

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Takeshi Kimura, M.D., Ph.D., Professor btn

The department of Cardiovascular Medicine at Kyoto University aims to elucidate cause of the cardiovascular diseases and its therapeutic measures by assessing both basic and clinical research approaches. We encourage young doctors to become well-balanced clinicians who focus not only on medical treatments but also on research and development of the disease prevention. Students and doctors are also encouraged and being trained to take an active role at global level. We strive to make high contributions in the area of cardiovascular medicine within Japan.

Research and Education

■Basic Research
・Our research groups conduct leading and innovative researches in the field of cardiovascular medicine based on a thorough understanding of the molecular biology, physiology, and molecular genetics. We keep in close contact with the clinical research groups at our department since both clinical and basic researches are essential for the progress of the cardiovascular medicine.
・We seek to expand the possibilities of our own researches. A participation of young researchers or those from different area of studies deepen and widen our researches, and we welcome new colleagues who are interested in our research.
・We aim to elucidate the pathophysiology of cardiovascular diseases and to develop diagnosis methods and therapeutic strategies. We also perform translational research with wide clinical application.
■Clinical Research
・Members of our department continue to contribute evidence-based health care through clinical researches and education in the fields of cardiovascular medicine. We constantly conduct numbers of clinical studies including multicenter randomized controlled trials in collaboration with major hospitals in Japan. The majority of research target include ischemic heart disease, heart failure, arrhythmia, peripheral artery disease, aortic disease, hypertension, and cardiac rehabilitation.

For further details, please visit our web site at : <http://kyoto-u-cardio.jp/

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Recent Publications

1.Taniguchi T, Morimoto T, Shiomi H, Ando K, Kanamori N, Murata K, Kitai T, Kawase Y, Izumi C, Miyake M, Mitsuoka H, Kato M, Hirano Y, Matsuda S, Nagao K, Inada T, Murakami T, Takeuchi Y, Yamane K, Toyofuku M, Ishii M, Minamino-Muta E, Kato T, Inoko M, Ikeda T, Komasa A, Ishii K, Hotta K, Higashitani N, Kato Y, Inuzuka Y, Maeda C, Jinnai T, Morikami Y, Sakata R, Kimura T ; CURRENT AS registry Investigators. Initial Surgical versus Conservative Strategies in Patients with Asymptomatic Severe Aortic Stenosis. J Am Coll Cardiol. 2015;66(25):2827-38.
2.Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, Ozawa T, Kurotobi T, Morishima I, Miura F, Watanabe T, Masuda M, Naito M, Fujimoto H, Nishida T, Furukawa Y, Shirayama T, Tanaka M, Okajima K, Yao T, Egami Y, Satomi K, Noda T, Miyamoto K, Haruna T, Kawaji T, Yoshizawa T, Toyota T, Yahata M, Nakai K, Sugiyama H, Higashi Y, Ito M, Horie M, Kusano KF, Shimizu W, Kamakura S, Kimura T; UNDER-ATP Trial Investigators. Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the UNmasking Dormant Electrical Reconduction by Adenosine TriPhosphate (UNDER-ATP) trial. Eur Heart J. 2015 36(46):3276-87.
3.Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. Circ Res 2015;116:279-288.
4.Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice, Nat Commun 2013;4.
5.Kimura T, Morimoto T, Natsuaki M, Shiomi H, Igarashi K, Kadota K, Tanabe K, Morino Y, Akasaka T, Takatsu Y, Nishikawa H, Yamamoto Y, Nakagawa Y, Hayashi Y, Iwabuchi M, Umeda H, Kawai K, Okada H, Kimura K, Simonton CA, Kozuma K; RESET Investigators. Comparison of everolimus-eluting and sirolimus-eluting coronary stents: 1-year outcomes from the Randomized Evaluation of Sirolimus-eluting Versus Everolimus-eluting stent Trial (RESET). Circulation. 2012 ;126:1225-36.

Cardiovascular Medicine

【Staff Members】
Professor:Takeshi Kimura
Associate Processor:Koh Ono
Senior Lecturer:Koichiro Kuwahara, Satoshi Shizuta
Assistant Professor:Yasuaki Nakagawa, Takeru Makiyama, Naritatsu Saito, Neiko Ozasa, Takao Kato, Masao Imai
Assistant Professor (Hospital):Junichi Tazaki, Hiroki Shiomi
Assistant Professor (Hospital – Clinical Laboratory):Yasuhiro Nakashima

Industry – Academia Collaboration
Associate Professor:Eiichiro Nishi
Senior Lecturer:Noboru Ashida
Assistant Professor:Mikiko Ohno, Takahiro Horie

Funded Laboratory
Associate Professor:Hideyuki Kinoshita
Assistant Professor:Yasuhide Kuwabara
TEL:+81-75-751-4254
FAX:+81-75-751-3289
e-mail:junkan@kuhp.kyoto-u.ac.jp
URL:http://kyoto-u-cardio.jp/