|Research and Education
* Biomedical imaging devices
We have been developing an ultra high resolution Magnetic Resonance Imaging (MRI) as a microscopy, "MRI Microscopy". Among imaging technologies, MRI is in an unique position due to its abilities to localize activating parts in biomedical specimen and to distinguish tissue non-invasively. With the MRI Microscopy, we could understand human brain functional images from the molecular and cell biological point of view. We started to develop a new MRI Microscope for small biological tissue using a 14.1 T horizontal bore magnet and a 600 MHz NMR spectrometer.
* Image processing methods and its medical applications
We develop image processing techniques for quantitative analysis of multi dimensional medical images including multi modality images or sequential images. We also develop medical applications such as image guided radiotherapy, image guided intervention, CAD(computer aided diagnosis) system, and so on. An example of the work is shown in the right column figure (4-dimensional cardiac MR tagged imaging and 5-dimensional image processing methods).
||Four-dimensional cardiac MR tagged imaging and image processing.|
||Previously developed MR microscope with 7-T magnet.|
||Staff with 14-T MR magnet for a new MR microscope.|
||M. Murashima, T. Ueno, K. Sakai, Y. Taniguchi, and N. Sugimoto, Postmortem 3D image comparison of wild type and p53 knockout medaka by MR microscope, Molecular Imaging and Biology, Vol.14, suppl.1, p.s378(2012)|
||K. Sakai, K. Yamada, and N. Sugimoto: Calculation methods for ventricular diffusion-weighted imaging thermometry: phantom and volunteer studies, NMR in Biomedicine, Vol.25, No.2, pp.340-346(2011)|
||K. Yamada, K. Sakai, N. Sugimoto, et. al, Moyamoya patients exhibit higher brain temperatures than normal controls, NeuroReport, Vol.21, pp.851-855(2010)|
||T. Ueno, S. Kanayama, N. Sugimoto, et al.,Development of 14.1 T MR Microscope. Molecular Imaging and Biology, 12 suppl.1, pp.S255-S256(2010)|
||S. Urayama, N. Sugimoto, et al., Four-dimensional MR tagged imaging and image processing. International Journal of Computer Assisted Radiology and Surgery, Vol. 1-Suppl., pp.107-109(2006)|