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 - Clinical Medicine (Core Departments) - Human Brain Research Center
Brain Pathophysiology / Functional Brain Imaging
Human Brain Research Center
We are engaged in the research works on the human brain function using non-invasive technique, such as MRI, PET, MEG, TMS and so on. Our main purpose is directed to disclose the functional localization and connectivity of the human brain, and research the physiological mechanisms of the disorders in the CNS. We think that it is the most important thing to explore the brain function from the various aspects using available imaging or physiological apparatus.

  Hidenao Fukuyama, M.D., Ph.D.
Research and Education
Recent advances on the molecular imaging stimulate us to do the work related this field. The basic concept is to expand the functional significance of the gene or subsequent protein products in vivo. The neuroscience itself is dedicated to find out the functions of the human brain, but we have to explore the animal brain for its final goal, because human brain is specific to human being and also we cannot do any invasive technique to the human brain except for the special occasions. It was reported that beta-amyloid is visualized using PET. In the near future, we can image the various kinds of proteins or other substances without invasive exploratory procedures. This is the dream and final direction of the neuroscience in one aspect.
Another is the research to help the disadvantaged brain with the knowledge of the normal brain functions. Rehabilitation is regarded as one of the regeneration medicine. HBRC is one of the departments that concern with the neuroscience and clinical neurology. Therefore, we have also keen interest in this aspect, and devote the efforts to make help for disadvantaged people.
We will welcome every person to join us and do the research activities, who have the similar interests.

Brain Pathophysiology/
Functional Brain Imaging
Human Brain Research Center
Professor Hidenao Fukuyama,
Denis Le Bihan

Tatsuya Mima,
Kimihiro Nakamura

Nobukatsu Sawamoto,
Shinichi Urayama,
Takashi Suzuki
TEL +81-75-751-3695
FAX +81-75-751-3202
306 channel whole-head MEG measures neuronal electrical activity at high temporal resolution.
3 tesla MRI scanner visualizes brain structure and function at high spatial resolution.
Tractography analysis of diffusion MRI data identifies connectivity among brain areas.
Member of the laboratory.
Recent Publications
1. Altmann CF, Matsuhashi M, Votinov M, Goto K, Mima T, Fukuyama H. Visual distance cues modulate neuromagnetic auditory N1m responses. Clin Neurophysiol. 2012.
2. Nakatsuka M, Thabit MN, Koganemaru S, Nojima I, Fukuyama H, Mima T. Writing's shadow: corticospinal activation during letter observation. J Cogn Neurosci. 2012;24:1138-48.
3. Otsuka Y, Yamauchi H, Sawamoto N, Iseki K, Tomimoto H, Fukuyama H. Diffuse tract damage in the hemispheric deep white matter may correlate with global cognitive impairment and callosal atrophy in patients with extensive leukoaraiosis. AJNR Am J Neuroradiol. 2012;33:726-32.
4. Tabu H, Mima T, Aso T, Takahashi R, Fukuyama H. Common inhibitory prefrontal activation during inhibition of hand and foot responses. Neuroimage. 2012;59:3373-8.
5. Nakamura K, Oga T, Takahashi M, Kuribayashi T, Kanamori Y, Matsumiya T, Maeno Y, Yamamoto M. Symmetrical hemispheric priming in spatial neglect: a hyperactive left-hemisphere phenomenon? Cortex. 2012.