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 - Clinical Medicine (Core Departments) - Clinical Neuroscience
Department of Neurology has served as an academic research center by educating students, residents, and staff towards professional values in neurosciences; neuropathology, neurochemistry, molecular neurobiology, and neurophysiology using molecular biology, molecular genetics, developmental engineering, pharmacology, electrophysiology, histology, and/or system brain science to achieve novel and efficient therapies for intractable neurological diseases.

  Ryosuke Takahashi, M.D.,Ph.D.
Research and Education
Department of Neurology consists of 4 laboratories.
In Neuropathology lab, we examine human autopsy brains in clinico-pathological conference, and further study with immunohistochemistry and neurochemical methods. Using genetically-modulated animals, we are doing research work on the pathogenesis and new therapeutic strategies for stroke and dementia, and neurodegenerative diseases (Figure 1).
In Neurochemistry lab, we study the molecular mechanism of neuronal death in neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS), and are trying to develop novel therapy for the diseases. For example we have revealed the nicotinic receptor-mediated neuroprotective cascade (Figure 2). Moreover, we study proteomics to investigate the pathogenesis and develop diagnostic methods in neurodegenerative disorders.
Molecular Neurobiology lab aims to provide novel preventive/therapeutic approaches towards sporadic Parkinson’s disease and ALS based on recent findings that misfolded proteins cause neurodegeneration either in familial Parkinson’s disease or familial ALS (Figure 3).
In Neurophysiology lab, we have aimed at elucidating the pathophysiology of the diseases of the central nervous systems involving the neuronal circuitry and functional organization such as epilepsy, movement disorders and higher cortical dysfunctions, and at promoting the new treatment approaches. We also have clarified the mechanism of higher cortical functions in humans such as motor control, language and sensory perception, all of which are always related to the relevant diseases (Figure 4).
For education, we provide students and residents with organized, educational course of researches.

Professor Ryosuke Takahashi

Akio Ikeda

Riki Matsumoto

Kengo Uemura,
Hirofumi Yamashita,
Hodaka Yamakado,
Akihiro Kitamura
TEL +81-75-751-4397
FAX +81-75-761-9780
Neuropathology lab accumulated 360 brains with a variety of neurological diseases. These diseases include cerebrovascular diseases, infection, tumor, neurodegenerative and demyelinating diseases. The brains are subjected to clinicopathological conference and examination with immunohistochemical and neurochemical methods.
Nicotinic receptor-mediated neuroprotection against apoptosis.
Recent Publications
1. Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y. and Takahashi, R. An unfolded putative membrane transmembrane olypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105, 891-902, 2001.
2. Kinoshita, M., Ikeda, A., Matsumoto, R., Begum, T., Usui, K., Yamamoto, J., Matsuhashi, M., Takayama, M., Mikuni, N., Takahashi, J., Miyamoto, S., and Shibasaki, H. Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes. Epilepsia 45: 787-791, 2004.