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 - Clinical Medicine (Core Departments) - Surgery for Sensory and Motor Systems
Oral and Maxillofacial Surgery
Department of Oral and Maxillofacial Surgery is committed with academic oral surgeon aiming to progress the clinical care, education, and scientific research. Our mission is to advance the modern diagnosis and treatment for dent-maxillofacial, oral and craniofacial disorders through innovative basic and clinical research. Based on Kyoto University’s highest intellectual and physical resources, we are maintaining the top level of patient’s care, residency and postgraduate education program, and frontier research.

  Kazuhisa Bessho, D.D.S.,D.M.Sc.
Research and Education
The current researches in our department are as follows.
Our major interest is to clarify the mechanisms of the onset of temporomandibular joint disorders (TMDs), especially "closed lock". In previous studies, our research unit has evaluated histopathologic and biochemical alterations of temporomandibular arthritis induced by mechanical loading in rabbits (arthritis animal models), because excessive loads on the glenoid fossa is thought one of the significant causes of TMDs. Also our research unit has analyzed concentration of proteins and cytokines in the synovial fluids of TMD patients. Now we have interest in methodologies of mass spectrometric analysis of hyaluronic acid in synovial fluids. Our research unit is analyzing normal and abnormal jaw function through refined recordings of muscle activity and jaw movement in 3 dimensional magnetic resonance imaging (MRI) and high speed MRI (HASTE method: figure ) for studying the detailed functions of the jaw muscles. These same methodologies are being applied to the study of jaw function in TMD patients to identify differences between TMD patients and normal persons. We think the outcomes from these studies should lead to a reduction of the burden that TMD causes on the medical practice. Uterine sensitization associated gene-1 (USAG-1) is a BMP antagonist that functions in the local regulation of BMP mediated signal transduction by binding and neutralizing BMP activities, and also modulates Wnt signaling . We previously reported that USAG-1 deficient mice have supernumerary teeth. The supernumerary maxillary incisor appears to form as a result of the successive development of the rudimentary upper incisor. USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. We confirmed that BMPs were expressed in both the epithelium and mesenchyme of the rudimentary incisor at E14 and E15. BMP signaling in the rudimentary maxillary incisor, assessed by expressions of Msx1 and Dlx2 and the phosphorylation of Smad protein, was significantly enhanced. Inhibition of BMP signaling rescues supernumerary tooth formation in E15 incisor explant culture. Based upon these results, we conclude that enhanced BMP signaling results in supernumerary teeth in the USAG-1 deficient mouse model. We constructed a BMP-2-expressing adenoviral vector with high efficiency and succeeded gene transfer by electroporation and sonoporation with a BMP-2-expressing plasmid vector. These bone regeneration methods may be useful in clinic. The pluripotential cells isolated from the pulp of human teeth and expanded in vitro, differentiated into osteoblasts, chondrocytes and adipocytes. We research about biomaterials and bone reconstruction using bone morphogenetic protein expressing vector. And we examine interactions between osteoinduction and chemicals. On the other hand, we research and develop new diagnosis devices, operation devices and dental implant in cooperation with Faculty of Engineering and enterprises.

Oral and Maxillofacial Surgery
Professor Kazuhisa Bessho

Kazuma Fujimura

Katsu Takahashi,
Junya Sonobe

Masashi Yamori,
Hiroyuki Takafuji,
Kayo Tamura
TEL +81-75-751-3401
FAX +81-75-761-9732
High speed MRI (HASTE)Left: Anterior displacement of disc without reduction
Osteoinduction by bone morphogenetic protein using transcutaneous sonoporation.
Supernumerary maxillary incisor in USAG-1 deficient mouse
Osteoinduction in the calf muscle of rat by bone morphogenetic protein-2-expressing recombinant adenoviral vector.
The research on the links between oral health and general health
Recent Publications
1. Yamazaki, T., Yamori, M., Ishizaki, T., Asai, K., Goto, K., Takahashi, K., Nakayama, T. and Bessho, K. Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: A cohort study. Int J Oral Maxillofac Surg. 2012, in press
2. Sakata-Goto T, Takahashi K, Kiso H, Huang B, Tsukamoto H, Takemoto M, Hayashi T, Sugai M, Nakamura T, Yokota Y, Shimizu A, Slavkin H, Bessho K. Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis, Bone. 2012, 50, 69-78
3. Fujimura K, Bessho K. Rigid fixation of intraoral vertico-sagittal ramus osteotomy for mandibular prognathism. J Oral Maxillofac Surg. 2012, 70, 1170-1173
4. Huang B, Takahashi K, Sakata T, Kiso H, Sugai M, Fujimura K, Shimizu K, Kosugi S, Sato T and Bessho K. Increased risk of TMJ closed lock: a study of ANKH polymorphisms, PLoS ONE, 2011, 6, e25503,
5. Koyama N, Okubo Y, Nakao K, Osawa K, Fujimura K, Bessho K. Pluripotency of mesenchymal cells derived from synovial fluid in patients with temporomandibular joint disorder. Life Sci. 2011, 89, 741-747