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 - Clinical Medicine (Core Departments) - Surgery for Sensory and Motor Systems
Orthopaedic Surgery
We, orthopaedic surgeons, treat patients who suffer diseases and injuries in the musculo-skeletal system. Most of the people experience knee or shoulder pain and low back pain in a lifetime. Femoral or vertebral fracture is the second popular cause that leads the elderly people to become bedridden. We believe that overcoming functional disability of the musculo-skeletal system contributes not only to the happiness of an individual patient but also to the welfare of our whole society. The first decade in the 21st century was the “Bone and Joint Decade”, in which the World Health Organization (WHO) promoted the world-wide improvement in the treatment of the musculo-skeletal disorders. We hope that all people can mobilize their healthy body without difficulties through their life.

  Shuichi Matsuda, M.D., Ph.D.
Research and Education
Clinical and basic researches are carried out intensively and vigorously in each group of specialists. We deal with many joint disease including hip joint diseases (osteoarthritis of the hip, avascular necrosis of the femoral head, etc), knee joint diseases (osteoarthritis of the knee, ligament injury, meniscal injury, etc), and other joint disease, rheumatoid diseases like rheumatoid arthritis. We also treat spinal diseases (disc herniation, ossification of the posterior longitudinal ligament, spinal tumors, etc), bone and soft tissue tumors (osteosarcoma, liposarcoma, etc), disorders in the upper extremity (amputated fingers, peripheral nerve palsy, etc), and so forth. Our department consists of 6 groups; hip surgery, sports medicine and knee/shoulder surgery, rheumatology, spine surgery, musculo-skeltal tumor surgery, and hand surgery. Each group has clinical conference and/or journal club at least once a week, where the surgeons heighten and refresh their clinical and surgical skills. We also try frontier diagnosis and treatment as members of world leading university.
We are also doing basic research working with post-graduate students and clinical fellows. Skeletal formation/functional regulation group is focusing on genome-wide and systemic analyses of gene and protein expression, function in skeletogenesis and bone and cartilage metabolism using molecular biological, biochemical, and mouse genetics approaches. Biomaterial group has developed many bioactive implants, some of which have been applied clinically. Recently good osteoconductive and osteoinductive titanium has been developed. Using this material, a new spinal fusion cage was made and used in patients as a clinical trial, with an excellent result. Knee group is developing a new knee prosthesis using computer simulation technology. Tumor group is researching on a molecular mechanism of generation of bone and soft tissue tumor and its application to clinical cases. Application of bone marrow stromal cells to necrotic lesion of femoral head or carpal bone is under clinical research, collaborated with Institute for Frontier Medical Science. Cartilage metabolism/rheumatology group is experimentally investigating the mechanism of joint destruction in osteoarthritis and rheumatoid arthritis, leading to future cartilage repair. Sports medicine and knee/shoulder surgery group is developing imaging systems in order to evaluate physical and structural properties of the cartilage for clinical applications. Peripheral nerve group is working on the nerve regeneration, once thought impossible, trying to apply the method for treating nerve degeneration and injury.

Orthopaedic Surgery
Professor Shuichi Matsuda

Haruhiko Akiyama

Shunsuke Fujibayashi,
Koji Yamamoto

Takeharu Nakamata,
Takeshi Okamoto,
Soichi Ohta,
Mitsuru Takemoto,
Kazutaka So,
Ryuzo Arai,
Yutaka Kuroda,
Bungo Ohtsuki
TEL +81-75-751-3652
FAX +81-75-751-8409
Development of ex vivo IBG instrument for revision total hip arthroplasty
Artificial bone modeling by Rapid prototyping method
Analysis of Transcriptional regulation of Sox9 using FACS-array gene expression analysis
A specially-made guide for pedicle screw insertion
Computer simulation after total knee arthroplasty
Recent Publications
1. Ishikawa M, Ito H, Akiyoshi M, Kume N, Yoshitomi H, Mitsuoka H, Tanida S, Murata K, Shibuya H, Kasahara T, Kakino A, Fujita Y, Sawamura T, Yasuda T, Nakamura T. Lectin-like oxidized LDL receptor-1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis. Arthritis Rheum. 64(4):1024-1034, 2012.
2. Nakamura Y, Yamamoto K, He X, Otsuki B, Kim Y, Murao H, Soeda T, Tsumaki N, Deng JM, Zhang Z, Behringer RR, Crombrugghe B, Postlethwait JH, Warman ML, Nakamura T, Akiyama H. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun.2,251, 2011.
3. Akiyama H, Yamamoto K, Tsukanaka M, Kawanabe K, Otsuka H, So K, Goto K, Nakamura T. Revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device with bone allograft: minimum 4.5-year follow-up results and mechanical analysis. J Bone Joint Surg Br. 93(9):1194-200, 2011.
4. Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Pattanayak DK, Matsushita T, Sasaki K, Nishida N, Kokubo T, Nakamura T. Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting. Acta Biomater. 7(5):2327-36, 2011.
5. Ohta S, Iwashita Y, Kakinoki R, Noguchi T, Nakamura T. Effects of continual intravenous infusion of MCI-186 on the functional recovery after spinal cord injury in rats. J Neurotrauma. 28(2):289-298, 2011.
6. Furu M, Kajita Y, Nagayama S, Ishibe T, Shima Y, Nishijo K, Uejima D, Takahashi R, Aoyama T, Nakayama T, Nakamura T, Nakashima Y, Ikegawa M, Imoto S, Katagiri T, Nakamura Y, Toguchida J. Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. Oncogene. 30(38):4015-25, 2011.
7. Arai R, Mochizuki T, Yamaguchi K, Sugaya H, Kobayashi M, Nakamura T, Akita K. Functional anatomy of the superior glenohumeral and coracohumeral ligaments and the subscapularis tendon in view of stabilization of the long head of the biceps tendon. J Shoulder Elbow Surg. 19(1):58-64, 2010