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 - Clinical Medicine (Core Departments) - Surgery for Sensory and Motor System
Plastic and Reconstructive Surgery
Plastic and reconstructive surgery is a specialized branch of surgery to repair deformities and defects of the integument and underlying musculocutaneous framework. In our field, we not only conduct clinical studies for improvement of surgical outcomes but also focus on basic research into wound healing and microcirculation of the skin and subcutaneous tissue. In addition, we had already begun to study skin regeneration before the phrase “regenerative medicine” became popular. One of our achievements in this area has already been commercialized. As well as skin regeneration, we have been studying regeneration of nerve, bone, cartilage and blood vessel. We will continue to perform clinically useful research.

  Shigehiko Suzuki, M.D., Ph.D.
Professor
Research and Education
Current research activities in our field deal with clinical studies regarding maxillofacial surgery, microsurgery, skin surgery and hand surgery, and basic studies regarding regenerative medicine, wound healing, cutaneous microcirculation and embryology.
In regenerative medicine, we first started to develop an artificial dermis in cooperation with the Institute for Frontier Medical Sciences. The artificial dermis composed of collagen sponge is spontaneously converted into a synthesized connective tissue matrix similar to the true dermis. The present version of our artificial dermis has been clinically used in the world. In addition, we have developed a new artificial dermis that can provide sustained release of cell growth factors and an autologous cultured dermal substitute containing autologous fibroblasts. We have conducted clinical trials of these two projects in cooperation with Translational Research Center, Center for Cell & Molecular Therapy and the department of dermatology. Furthermore, we have been conducting research on skin-derived precursor cells (SKPs) and the regenerative mechanism of elastic fibers with a view to developing an ideal cultured skin. In addition, we have been studying preservation of the skin and skin substitutes. As for regeneration of cartilage, we identified progenitor cells in the ear perichondrium and are now developing novel scaffolds for clinical application. Furthermore, we have been engaged in studies on regeneration of the central nervous system, peripheral nerves, cartilage, bone and micro vessels.
In wound healing, we are putting a great deal of effort into elucidating the origins of keloid tissue and hypertrophic scars and developing fundamental treatments for these problems. In addition, we have been engaged in preparing iPS cells to clarify the pathogenesis of neurodegenerative and cutaneous diseases in collaboration with CiRA (Center for iPS Cell Research and Application) and the department of neurology.
Such basic research is closely related to clinical applications. We regard a clinically useful study as highly important in our field and we are training young researchers to have both scientific and clinical perspectives and to aim at performing creative studies.


Plastic and Reconstructive Surgery
Professor Shigehiko Suzuki
Associate
 Professor


Katsuya Kawai
Senior
 Lecturer


Motoko Naitoh
Assistant
 Professor


Toshihiro Ishiko,
Norikazu Kanda,
Katsuhiro Yoshikawa,
Hiromu Masuoka
TEL +81-75-751-3613
FAX +81-75-751-4340
e-mail prskuhp.kyoto-u.ac.jp
URL http://www.kuhp.kyoto-u.ac.jp/~keisei/
Recent Publications
1. Ayvazyan A.,Morimoto N.,Kanda N.,Takemoto S,.Kawai K,Sakamoto S.,Taira T,.Suzuki S. Collagen-Gelatin Scaffold Impregnated with bFGF Accelerates Palatal Wound Healing of Palatal Mucosa in Dogs. Journal of Surg Res. 171: e247-e257, 2011.
2. Morimoto,N.,Takemoto,S.,Kanda,N.,Ayvazyan,A.,Taira,T.,Suzuki,S.:The Utilization of animal product-free media and autologous serum in an autologous dermal substitute culture. J Surg Res. 171:339-346, 2011.
3. Ikeda, M., Naitoh, M., Kubota, H., Ishiko, T., Yoshikawa, K., Yamawaki, S., Kurokawa, M., Utani, A., Nakamura, T., Nagata, K., Suzuki, S.: Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloids. Biochem. Bioph. Res. Co. 390: 1221-1228, 2009.
4. Takemoto, S., Morimoto, N., Kimura, Y., Taira, T., Kitagawa, T., Tomihata, K., Tabata, Y., Suzuki, S.: Preparation of collagen/gelatin sponge scaffold for sustained release of bFGF. Tissue Eng. 14: 1629-1638, 2008.
5. Kawazoe, T., Kim, H., Tsuji, Y., Morimoto, N., Hyon, S.H., Suzuki, S.: Green tea polyphenols affect skin preservation in rats and improve the rate of skin grafts. Cell Transplantation 17: 203-209, 2008.
Immunohistochemical analysis of elastic fiber components in normal skin tissues (a) and keloids(b).
Skin-derived precursor cells (SKPs), which are multipotent progenitor cells, have been isolated from adult human dermis.
Researchers and graduate students of our department.
Tissue engineered cartilage using a novel scaffold (a) and its microscopic appearance (b).
Preparing autologous cultured dermis for clinical trial in Cell Processing Center.
Prepared autologous cultured dermis.