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 - Clinical Medicine (Core Departments) - Surgery for Visceral Organs
Thoracic Surgery
Department of Thoracic Surgery, Kyoto University, was founded in 1941 and involved into a leading international thoracic surgery program from one of the earliest such programs in Japan. Clinically, we are dealing with various diseases of the lung and mediastinum. For increasing lung cancer surgery, video-assisted thracoscopic surgery has become a standard approach in our department. A new Kyoto Lung Transplant Program was developed by Professor Date who had done a majority of lung transplants in Japan. Between June 2008 and December 2009, the new program performed living-donor lobar lung transplantation in eight sick patients resulting in all success. We have accepted a number of foreign visitors for observing such operation. Thoracic surgeons trained in our department are practicing in affiliated hospitals mainly in the west part of Japan. Over 2,300 cases of lung cancer surgery (about 10% of cases in whole Japan) are performed annually by our group.

  Hiroshi Date, M.D., Ph.D.
Professor
Research and Education
Faculty research within the Department of Thoracic Surgery encompasses a wide range of interests including lung cancer, lung transplantation and regenerative medicine. For lung cancer research, we are looking for prognostic factors after lung cancer surgery using specimens removed in OR. Especially, EGFR mutations and EML4-ALK fusion gene have been extensively investigated in our laboratory. Preoperative as well as postoperative chemotherapy and/or chemo-radiotherapy for lung cancer have been studied both in the clinic and in the laboratory so as to identify useful biological makers for “order made treatment”. For lung transplant research, we have developed ET-Kyoto solution for preservation and this solution is now clinically used in various institutions. We are conducting studies on lung transplantation from donors after cardiac death using an ex-vivo lung perfusion animal model. We have found that forced oscillation technique may be useful in detecting rejection after lung transplantation. We first successfully performed a bilateral native lung sparing living-donor lobar lung transplantation which can be applied to large adult recipients. The Department of Thoracic Surgery provides education and treatment of the full range of complex general thoracic problems regarding diagnoses, examinations and surgical and non-surgical therapies.


Thoracic Surgery
Professor Hiroshi Date
Associate
 Professor


Zhenglong Huang
Senior
 Lecturer


Hiroaki Sakai,
Makoto Sonobe
Assistant
 Professor


Tsuyoshi Shoji,
Fengshi Chen,
Toshihiko Sato
TEL +81-75-751-4975
FAX +81-75-751-4974
e-mail hdatekuhp.kyoto-u.ac.jp
URL http://www.thoracic-kyoto-u.gr.jp/
Lung transplantation
Bilateral native lung sparing living-donor lobar lung transplantation
Ex-vivo lung perfusion model
Novel EML4-ALK variants
Department picture
Recent Publications
1. Date H, et al. Improved survival after living-donor lobar lung transplantation. J Thorac Cardiovasc Surg 128:933-40, 2004
2. Chen F, et al. Prognositc factors of pulmonary metastasectmy for osteosarcomas of the extrimities. Eur J Cardiovasc Surg 34:1235-9, 2008
3. Satoda N, et al. Value of FOXP3 expression in peripheral blood as rejection maker after miniature swine lung transplantation. J Heart Lung Transplant 27:1293-301, 2008
4. Date H. Diagnostic strategies for mediastinal tumors and cysts. Thorac Surg Clin 19:29-35, 2009
5. Iwakiri S, et al. Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsamll cell lung cancer. Cancer 115:2580-93, 2009
6. Takahashi T, et al. Clinicopathologic feasures of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol 2009 (Epub ahead of print)