It is printed in the A4 size.To the laboratory site

 - Clinical Medicine (Core Departments) - Surgery for Visceral Organs
Urology comprehends a wide range of medical field. Among them, the main interests of our department are in urologic oncology, and in benign diseases including voiding function, transplantation, reproductive medicine, and pediatric urology.
In urologic oncology, in particular, we have a long track record of having introduced innovative therapies such as new anticancer drug treatments for urogenital tumors, new types of operation for urinary diversion, and laparoscopic urologic surgeries, of which we have taken the leadership in Japan.
The basic policy of our department is to carry out the advanced medicine based on active propulsion of research and education. We offer, not only the standard medical treatments, but highly advanced medical treatments to the patients by constantly introducing the state-of the-art technology and updated knowledge of the time.

  Osamu Ogawa, M.D., Ph.D
Research and Education
As an important part of the surgical section, we try to bring up top quality urologists with sophisticated surgical techniques, who can analyze complicated pathology of urological diseases properly and manage appropriate treatments for the patients. We believe that this task will be efficiently achieved by performing practice of advanced medicine in an education-oriented environment.
We have maintained a largest number of endourological surgery, including laparoscopic surgery, in Japan. Therefore, we believe that we can offer an optimal educational environment to young physicians trained as urologic surgeons and educator. Actually, we run a new education program for specialty training in cooperation with the affiliated hospitals since 2006.
On research field, we prioritize the practical science that can contribute to real medical treatments. In our lab, more than 10 postgraduate students are engaged in urologic research, and continue to send the high quality results to prestigious international journals. In our major fields such as urologic oncology, voiding function, transplantation, or reproductive medicine, we encourage collaboration with various basic research sections in our university and the foreign laboratories.
In addition, we always have several young urologists engaged in research abroad, who will contribute to maintain the research activity at the top-level of the world.
In the research area of urological oncology, we have made substantial contribution in the elucidation of the carcinogenic mechanism by using molecular biological methods and the determination of the hereditary cancer risk using molecular epidemiological approach. Recently, we are also actively working with a more clinically relevant anima model system, patient-derived xenograft model in mice. In the area of benign diseases, we have conducted researches on kidney transplantation as well as the outstanding studies on regeneration of the lower urinary tract. More recently, we are now making innovative achievements in the field of voiding dysfunction, by introducing molecular cellular biological approach in this field. In the area of andrology, we conduct basic researches on the mechanism of male infertility.

Professor Osamu Ogawa

Koji Yoshimura

Tomomi Kamba

Kazutoshi Okubo,
Takahiro Inoue,
Yousuke Shimizu,
Yoshiyuki Matsui,
Masaaki Imamura,
Toshinari Yamasaki,
Yoshio Sugino
TEL +81-75-751-3325
FAX +81-75-761-3441
Laparoscopic urologic surgery
Mouse bearing xenograft established from clinical cancer specimen
Molecular cellular approach to the urological diseases as a backbone of the basic research
The members of our department
Recent Publications
1. Shimizu Y, Hamazaki Y, Hattori M, Doi K, Terada N, Kobayashi T, Toda Y, Yamasaki T, Inoue TA, Kajita Y, Maeno A, Kamba T, Mikami Y, Kamoto T, Yamada T, Kanno T, Yoshikawa K, Ogawa O, Minato N, Nakamura E. Kobayashi T, Inoue T, Shimizu Y, Terada N, Maeno A, Kajita Y, Yamasaki T, Kamba T, Toda Y, Mikami Y, Yamada T, Kamoto T, Ogawa O, Nakamura E. SPA-1 controls the invasion and metastasis of human prostate cancer. Cancer Sci. 2011 (in press)
2. Akamatsu S, Takata R, Ashikawa K, Hosono N, Kamatani N, Fujioka T, Ogawa O, Kubo M, Nakamura Y, Nakagawa H. Hum Mol Genet. A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression. 2010, 9:4265-72.
3. Kobayashi T, Inoue T, Shimizu Y, Terada N, Maeno A, Kajita Y, Yamasaki T, Kamba T, Toda Y, Mikami Y, Yamada T, Kamoto T, Ogawa O, Nakamura E. Activation of Rac1 is closely related to androgen-independent cell proliferation of prostate cancer cells both in vitro and in vivo Mol Endcrinol, 2010, 24: 722-34.
4. Terada N, Shimizu Y, Kamba T, Inoue T, Maeno A, Kobayashi T, Nakamura E, Kamoto T, Kanaji T, Maruyama T, Mikami Y, Toda Y, Matsuoka T, Okuno Y, Tsujimoto G, Narumiya S, Ogawa O. Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. Cancer Res, 2010, 70: 1606-15.
5. Imamura M, Negoro H, Kanematsu A, Yamamoto S, Kimura Y, Nagane K, Yamasaki T, Kanatani I, Ito N, Tabata Y, Ogawa O. Basic fibroblast growth factor causes urinary bladder overactivity through gap junction generation in the smooth muscle. Am J Physiol Renal Physiol 2009, 297:F46-54. 2009