It is printed in the A4 size.To the laboratory site

 - Clinical Medicine (Core Departments) - Laboratory of Diagnostic Pathology
Diagnostic Pathology
TheDepartment of Diagnostic Pathology was established in 1980, and has long been recognized as a branch laboratory of investigative pathology and clinical pathology.Diagnostic pathology is a clinical application of “omics”-related science and traditional anatomic pathology, contributing todetermination of treatment strategy and evaluation of effects of treatment.In accordance with reorganization of the departments of investigative pathology,our department is now responsible for all autopsies and education of systemic pathology for undergraduate students as well as examination and interpretation of surgical specimens and cytopathological specimens in Kyoto University.

  Hironori Haga
Research and Education
Members of the department are experts in surgical pathology of several organs and some specific diseases. They pursue individual research projects in close cooperation with clinicians and other biomedical researchers. Most of our researches are clinically oriented, and our goal is to provide accurate and scientific diagnosis based on histology and cytology.
Current clinical researches include 1) analysis of allograft rejection and other complications after organ transplantation, 2) new methods of diagnosis and management of endocervical adenocarcinoma, 3) study on IgG4-related diseases and immunodeficiency-associated lymphoproliferative disorders.Other current and previous study included analysis of duodenal cancer, lung cancer, bone tumors, and so on. More basic themesare 1) elucidation of JAK2/STAT5 pathway in development of hematologic malignancies, 2) chimerism and senescence of the liver allograft, and 3) treatment of mast cell disorders. In addition to these studies initiated by pathology members, we are involved in several projects lead by clinicians, including central review of diagnosis of breast cancer and malignant lymphomas.
Education for graduate students is combination of research and advanced training for diagnostic pathology. Subspecialty training for surgical pathology or cytopathology is encouraged in combination with basic investigative research and/or traditional pathology study using immunohistochemistry and in situ hybridization. Complete in-house digital pathology database, image analysis using virtual microcopy, and tissue microarray techniqueare also available.

Diagnostic Pathology
Professor Hironori Haga

Yoshiki Mikami,
Sachiko Minamiguchi

Aya Miyagawa-Hayashino

Shinji Sumiyoshi,
Tatsuki R Kataoka,
Manabu Kurosawa
TEL +81-75-751-3488
FAX +81-75-751-3499
Recent Publications
1. Tsuruyama T, Fujimoto Y, Yonekawa Y, Miyao M, Onodera H, Uemoto S, Haga H. Invariant natural killer T cells infiltrate intestinal allografts undergoing acute cellular rejection. Transpl Int. 2012;25:537-44.
2. Murakawa Y, Miyagawa-Hayashino A, Ogura Y, Egawa H, Okamoto S, Soejima Y, Kurosawa M, Sumiyoshi S, Uemoto S, Haga H. Liver transplantation for severe hepatitis in patients with common variable immunodeficiency. Pediatr Transplant. 2011 Aug 10. [Epub ahead of print]
3. Mikami Y, Kiyokawa T, Sasajima Y, Teramoto N, Wakasa T, Wakasa K, Hata S. Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia. Histopathology. 2009;54:184-91.
4. Fujimoto M, Haga H, Okamoto M, Obara E, Ishihara M, Mizuta N, Nishimura K, Manabe T. EBV-associated diffuse large B-cell lymphoma arising in the chest wall with surgical mesh implant. Pathol Int. 2008;58:668-71.
5. Yamashita K, Haga H, Kobashi Y, Miyagawa-Hayashino A, Yoshizawa A, Manabe T. Lung involvement in IgG4-related lymphoplasmacytic vasculitis and interstitial fibrosis: report of 3 cases and review of the literature. Am J Surg Pathol. 2008;32:1620-6.
Endothelial chimerism. Original donor endothelium (green) mixed with recipient-derived endothelial cells (brown) reflecting portal fibrosis and neovessel formation.
C4d-positive chronic rejection after liver transplantation.
IgG4-related lung disease showing vasculitis with IgG4-positive plasma cells.
Automated multi-color quantitative fluorescent immunohistochemical morphometry for analysis of intestinal allograft rejection