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 - Clinical Medicine (Core Departments) - Developmental Medicine
The most important issue at Department of Pediatrics is development. A number of pediatric disorders are derived from the impairments during developmental process and the investigations disclosing the intrinsic defects lead to the exploitation of new diagnosis and treatment for intractable diseases. We would like to apply our outcomes obtained from clinic and laboratory to children with intractable diseases.

  Toshio Heike
Research and Education
Several projects on stem cell research and regenerative medicine are on progress. We are dealing with wide variety of stem cells such as hematopoietic stem cells, bone marrow-derived multipotent stem cells, skeketal or cardiac muscle stem cells, neural stem cells, liver stem cells including somatic stem cells and embryonic stem cells in a mouse, monkey and a human. We are aiming for the clinical application using these cells.
We have developed a new immunocompromised mouse, NOD/SCID/gamma c null mouse, which permits the engraftment and reconstitution of transplanted human cells. The development of this mouse enabled in vivo evaluation of human stem cells for the first time, leading to the establishment of reliable and safe regenerative medicine using human stem cells.

Professor Toshio Heike

Masahiko Kawai,
Ryuta Nishikomori

Ken-ichiro Watanabe,

Hiraku Doi,
Takahiro Yasumi,
Takeo Kato,
Yasunari Yamanaka,
Fusako Niwa,
Shinji Kaichi,
Katsutsugu Umeda,
Shiro Baba,
Tomonari Awaya,
Takeshi Hasegawa,
Itaru Kato,
Hidefumi Hiramatsu
TEL +81-75-751-3290
FAX +81-75-752-2361
ES-derived satellite-like cells can repair damaged muscle in vivo.
Selective and efficient detection of latent mutation of CIAS1 gene in mosaic CINCA syndrome
Recent Publications
1. Morishima T, Watanabe KI, Niwa A, Fujino H, Matsubara H, Adachi S, Suemori H, Nakahata T, Heike T.: Neutrophil Differentiation From Human-Induced Pluripotent Stem Cells. J Cell Physiol. 2011
2. Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, Okawa K, Abe T, Oshima N, Nakahata T, Heike T.: Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010
3. Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.:Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. Cardiovasc Res. 2010
4. Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukuda S, Yamamoto H, Yamanaka S, Nakahata T, Heike T: Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. FASEB J 24:2245-2253, 2010.
5. Sakai H, Ito S, Nishikomori R, Takaoka Y, Kawai T, Saito M, Okafuji I, Yasumi T, Heike T, Nakahata T: A case of early-onset sarcoidosis with a six-base deletion in the NOD2 gene. Rheumatology 49:194-62009.