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 - Clinical Medicine (Core Departments) - Internal Medicine
Respiratory Medicine
Respiratory diseases have marked variability such as obstructive airway diseases, interstitial lung diseases, lung cancer, respiratory infection, sleep disorders and respiratory insufficiency. We are energetically engaged in the study of all these diseases. In the 21st century, the concept “physiome”, which means that the integration of the achievement of molecular-cell biology form the view point of organ biology, will be more important. We hope we can create a new world of respiratory medicine based on “physiome”.

  Michiaki Mishima, M.D., Ph.D.
Research and Education
Our clinical, educational and research activities are performed on five categories; obstructive pulmonary disease, interstitial pulmonary disease, lung cancer, respiratory infection and sleep disorders / pulmonary insufficiency.

(1) Obstructive pulmonary disease (bronchial asthma, COPD)
We study how to control the refractory asthma and cough variant asthma, and investigate the etiology of COPD. The type of inflammation of airway in smokers, disease susceptibility of COPD and the mechanism of airway remodeling in refractory asthma are also studied.

(2) Interstitial pneumonia (sarcoidosis, idiopathic interstitial pneumonia and collagen disease related lung)
The mechanism of the variability of pulmonary fibrosis, lymphocyte proliferation and regulation of T cell in the process of fibrosis are investigated.

(3) Lung cancer
The recent prolongation of the life span in patients with the advanced lung cancer is indebted to the anticancer drugs of the third generation, and we are now performing multi-center clinical trial to find the best combination of the drugs. The metastatic factor of the lung cancer and the side effects of the molecular targeted drugs are also investigated.

(4) Respiratory infection
Genomic analysis and development of vaccines of TB and atypical mycobacterium and another bacteria are investigated. The immune system of the host is also studied.

(5) Sleep disorders / pulmonary fibrosis
The optimized protocol of non-invasive positive pressure ventilation (NIPPV) is investigated toward the patients with pulmonary insufficiency and sleep disorders such as obstructive sleep apnea. The effect of NIPPV on the life span is also studied based on adhesion molecule and inflammatory cytokine.

Respiratory Medicine
Professor Michiaki Mishima

Toyohiro Hirai

Hisako Matsumoto,
Yuyaka Ito,
Kim Younghhak,
Yuma Hoshino,
Isao Ito,
Tsuyoshi Oguma,
Kiminobu Tanizawa
TEL +81-75-751-3830
FAX +81-75-751-4643
Original CT image and colored image of pulmonary emphysema, where each emphysema cluster was described in the different colors.:
Fractal analysis using size and number of emphysema clusters offers useful information about the detection of early emphysema.
Comparison of the airway wall between the different stage of bronchial asthma:
The airway wall thickened as the stage of asthma progressed. CT images can detect the permanent change of airway wall construction (airway remodeling) in vivo.
Recent Publications
1. Terada K, Muro S, Sato S, et al. Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation. Thorax 2008;63:951-5
2. Ueda T, Niimi A, Matsumoto H, Takemura M, et al. TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. J Allergy Clin Immunol 2008;121:659-64.
3. Masago K, Fujita S, Kim YH,et al. Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer. Cancer Sci. 2009;100:1917-22.
4. Handa T, Nagai S, Kitaichi M, et al. Long-term complications and prognosis of chronic beryllium disease. Sarcoidosis Vasc Diffuse Lung Dis 2009;26:24-31.
5. Osawa M, Ito Y, Hirai T, et al. Risk factors for invasive aspergillosis in living donor liver transplant recipients. Liver Transpl. 2007;13:566-70.