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 - Clinical Medicine (Core Departments) - Internal Medicine
Gastroenterology and Hepatology
Our department has been established in 1996 as the first Department of Gastroenterology and Hepatology in all the national university in Japan. At that time, because our staff members and graduate students got together from various places in and outside of Kyoto university, the present members consist of a wide variety of people, whose carrier and medical school vary. As a clinical department, our goal is to produce many good clinical specialists for gastroenterology, who can understand both clinical medicine and basic science, and to create new modalities for treatment of various gastroenterological diseases.

  Tsutomu Chiba, M.D., Ph.D.
Research and Education
Periods of internship and residency are very important for young doctors to become good physicians. So, we are doing our best to educate young doctors to become general internists as well as good gastroenterologists. In particular, after finishing internship and residency, we prepare a special course for training clinical gastroenterology together with many affiliated hospitals. Similar to clinical works, our research projects cover liver diseases, pancreatico-biliary diseases, and upper and lower gastrointestinal tract diseases. Particularly, we are focusing on cancers, immunological diseases such as inflammatory bowel disease, and regeneration of gastrointestinal organs. Now, in order to enhance our ability of accomplishing research, we are sending young fellows to several distinguished research laboratories of basic medical science. In addition, there are quite a few young investigators, who are now doing research work in abroad. For these 17 years after establishment, we have clarified significance of occult infection of HBV in the development of liver cancer, roles of immunological responses to H. pylori in the development of various gastric diseases such as gastric cancer and MALT lymphoma, and have developed a novel method for treatment of IBD. Moreover, we made significant contribution to establishing the concept of autoimmune pancreatitis, and methods for treating post-operative biliary stricture after living-related liver transplantation. From now, we are going to establish treatment methods for various gastrointestinal cancers and IBD, and to develop method for regeneration of liver, that can substitute liver transplantation.

Gastroenterology and Hepatology
Professor Tsutomu Chiba

Manabu Muto,
Norihiko Watanabe,
Tomohiro Watanabe

Hiroshi Nakase,
Hiroshi Seno,
Hiroyuki Marusawa,
Yoshihide Ueda

Shinichi Miyamoto,
Yasumasa Ezoe,
Takahiro Horimatsu,
Shuko Morita,
Yuzo Kodama,
Yuko Matsumoto,
Minoru Matsuura,
Norimitsu Uza,
Ken Takahashi,
Takuya Yoshino
TEL +81-75-751-4319
FAX +81-75-751-4303
Histology of the gastric mucosa of H. pylori-infected neonatally thymectomized mice.
Massive infiltration of lymphocytes forming lymphoid follicles in the body mucosa at 12 months after H. pylori infection in neonatally thymectomized mice, which resembles histology of human MALT lymphoma.
While early detection of squamous cell carcinomas in the head and neck
region and the esophagus have been quite difficult by conventional white
light image (A), NBI can effectively detect them.
Recent Publications
1. Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, Azuma T, Okazaki IM, Honjo T, Chiba T: Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 13:470-476:2007.
2. Ikeda K, Marusawa H, Osaki Y, Nakamura T, Kitajima N, Yamashita Y, Kudo M, Sato T, Chiba T: Antibody to hepatitis B core antigen and risk for hepatitis C-related hepatocellular carcinoma: a prospective study. Ann Intern Med 146:649-656:2007.
3. Matsumoto Y, Marusawa H, Kinoshita K, Niwa Y, Sakai Y, Chiba T : Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. Gastroenterology 139:1984-1994:2010
4. Takai A, Marusawa H, Minaki Y, Watanabe T, Nakase H, Kinoshita K, Tsujimoto G, Chiba T: Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation. Oncogene 31:1733-1742:2012.
5. Aoki N, Kido M, Iwamoto S, Nishiura H, Maruoka R, Tanaka J, Watanabe T, Tanaka Y, Okazaki T, Chiba T, Watanabe N: Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice. Gastroenterology 140:1322-1333:2011.