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 - Clinical Medicine (Core Departments) - Internal Medicine
Medicine and Clinical Science
Recent studies demonstrate that not only classical endocrine organs but also virtually every tissue and organ possess the endocrine function. Based on this new concept of endocrinology and metabolism, we, the members of Department of Medicine and Clinical Science (Endocrinology and Metabolism) are focusing upon the diseases of endocrinology and metabolism, especially Metabolic Syndrome, which is so-called “life style-related diseases,” such as obesity, diabetes mellitus, hypertension and hyperlipidemia, and is the cluster of risk factors for atherosclerosis. We are investigating the pathogenesis of the syndrome and its complications, and performing translational research for the development of new therapeutic strategies.

  Kazuwa Nakao, M.D., Ph.D.
Research and Education
Department of Medicine and Clinical Science (Endocrinology and Metabolism) was founded in 1899 and has the history more than 110 years. Since 1992, under the supervision of Dr. Kazuwa Nakao, Professor and Chairman, the members of the department are engaged in the research activity aiming at the establishment of frontier medicine, in addition to the investigation on classical endocrine and metabolic diseases. Our goal is to achieve the elucidation of pathogenesis and the prevention of “life style-related diseases,” such as obesity, diabetes mellitus, hypertension, and their complications, and to develop new therapeutic strategies. In education and clinical services, our department is devoted to fostering expert doctors for endocrinology and metabolism and related fields, who can perform high quality and up-to-date diagnostic procedures and treatments. Furthermore, based upon the characteristics of endocrinology and metabolism to approach the maintenance of internal milieu, we aim at training “Physician Scientist” who can evaluate the patient as a whole and grasp the whole picture of pathophysiology the patient exhibits. Recently, as Japanese life-style is being westernized, Metabolic Syndrome, the cluster syndrome of obesity, diabetes mellitus, hypertension and hyperlipidemia, and its complications have been emphasized as an important social issue. We therefore focus especially upon this medical field and do comprehensive and advancing medical practice. In research activities, in order to achieve translational research which links basic research with clinical applications, we are performing molecular medical approach with molecular biology, molecular genetics and developmental biology to elucidate the pathogenesis and develop new therapeutic methods in the field. We, actually, have succeeded in achieving the clinical application of new hormones, natriuretic peptides, secreted from the cardiovascular organs, which have long been considered to be the pump or the vessel for circulation, and leptin, secreted from the adipose tissue, which is believed as the mere storage tissue for energy. We are also performing the research project of vascular regeneration medicine for vascular complications of the life style-related diseases, using human embryonic stem (ES) cells and iPS cells, as one of the first research groups in Japan.

Medicine and Clinical Science
Professor Kazuwa Nakao

Masashi Mukoyama

Koichiro Kuwahara,
Akihiro Yasoda

Yasuaki Nakagawa,
Junji Fujikura,
Hideki Yokoi,
Naotestu Kanamoto,
Hiroyuki Ariyasu,
Toru Kusakabe
Lecturer(Special Appointment):     Masako Miura,Masakatsu Sone
Assistant Professor(Special Appointment):Hideyuki Kinoshita, Nobuko Goto,
Noriaki Koyama
TEL +81-75-751-3168
FAX +81-75-761-1195
Recent Publications
1. T. Tanaka, H. Masuzaki, S. Yasue, K. Ebihara, T. Shiuchi, T. Ishii, N. Arai, M. Hirata, H. Yamamoto, T. Hayashi, K. Hosoda, Y. Minokoshi, and K. Nakao. Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet. Cell Metab. 5: 395-402, 2007.
2. J. Fujikura, K. Hosoda, H. Iwakura, T. Tomita, M. Noguchi, H. Masuzaki, K. Tanigaki, D. Yabe, T. Honjo, and K. Nakao. Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab. 3: 59-65, 2006.
3. A. Yasoda, Y. Komatsu, H. Chusho, T. Miyazawa, A. Ozasa, M. Miura, T. Kurihara, T. Rogi, S. Tanaka, M. Suda, N. Tamura, Y. Ogawa, and K. Nakao. Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway. Nat. Med. 10: 80-86, 2004.
4. K. Kuwahara, Y. Saito, M. Takano, Y. Arai, S. Yasuno, Y. Nakagawa, N. Takahashi, Y. Adachi, G. Takemura, M. Horie, Y. Miyamoto, T. Morisaki, S. Kuratomi, A. Noma, H. Fujiwara, Y. Yoshimasa, H. Kinoshita, R. Kawakami, I. Kishimoto, M. Nakanishi, S. Usami, Y. Saito, M. Harada, and K. Nakao. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J. 22: 6310-6321, 2003.
5. K. Yamahara, H. Itoh, T. Chun, Y. Ogawa, J. Yamashita, N. Sawada, Y. Fukunaga, M. Sone, T. Yurugi-Kobayashi, K. Miyashita, H. Tsujimoto, H. Kook, R. Feil, D. L. Garbers, F. Hofmann, and K. Nakao. Significance and therapeutic potential of natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration. Proc. Natl. Acad. Sci. USA, 100: 3404-3409, 2003.
6. J. Yamashita, H. Itoh, M. Hirashima, M. Ogawa, S. Nishikawa, T. Yurugi, M. Naito, K. Nakao, and S. Nishikawa. Flkl-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408: 92-96, 2000.