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 - Clinical Medicine (Core Departments) - Internal Medicine
Hematology and Oncology
Hematology is one of the areas in which active interactions and mutual stimulations between clinical medicine and basic science have been producing remarkable progress. We are trying to obtain deeper insights into mechanisms of and develop effective treatments for various hematological diseases, with a motto, “from bedside to bench, from bench to bedside”.

  Akifumi Takaori
Research and Education
For cure of hematological malignancies and infectious diseases, we are engaged in several research projects of both basic and clinical approaches. Ongoing clinical research projects are as follows: 1. functional analysis of dendritic cells and its application to the immunotherapy of hematological malignancies, and 2. cell-mediated immunotherapy for hematological malignancies including adult T-cell leukemia using hematopietic stem cell transplantation. Basic approaches to hematological and infectious diseases include: 1. functional analysis of phagocytes and other cells involved in the innate and acquired immune systems, 2. analysis of the function and expression of molecules related to iron metabolism, 3. research on the tumorigenesis and pathology of various hematological malignancies including malignant lymphoma, adult T-cell leukemia and MDS/MPD, and 4. elucidation of the mechanisms by which HIV-1 Vif and an antiviral host factor, APOBEC3G, regulate the infectivity of HIV-1. Motivations for these basic research projects have also been arisen during our daily clinical work. We are making efforts to keep pace with rapid advances in hematology, and wish to contribute much to its further progress.

Hematology and Oncology
Professor Akifumi Takaori

Norimitsu Kadowaki

Hiroshi Kawabata,
Kouhei Yamashita,

Tadakazu Kondo,
Toshiyuki Kitano,
Momoko Nishikori,
Masayuki Kobayashi,
Masakatsu Hishizawa,
Toshio Kitawaki,
Keisuke Shindo,
Masahiro Kawahara
TEL +81-75-751-3150
FAX +81-75-751-3201
Immunohistochemical detection of PD-1 ligands in Hodgkin/Reed-Sternberg cells. (A) H&E, (B) CD30, (C) B7-H1, (D) B7-DC.
Vif induces G2 cell cycle arrest in the presence of p53.
Bortezomib inhibits trafficking of TLR9, but not of Unc93b, from the ER to endolysosomes induced by CpG ODN. (A, B) TLR9: green, lysosome: red. (C, D) Unc93B: green, lysosome: red.
Recent Publications
1. Hirai, M., Kadowaki, N., Kitawaki, T., Fujita, H., Takaori-Kondo, A., Fukui, R., Miyake, K., Maeda, T., Kamihira, S., Miyachi, Y. & Uchiyama, T. (2011). Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis. Blood 117, 500-9.
2. Izumi, T., Io, K., Matsui, M., Shirakawa, K., Shinohara, M., Nagai, Y., Kawahara, M., Kobayashi, M., Kondoh, H., Misawa, N., Koyanagi, Y., Uchiyama, T. & Takaori-Kondo, A. (2010). HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication. Proc Natl Acad Sci U S A 107, 20798-803.
3. Hishizawa, M., Kanda, J., Utsunomiya, A., Taniguchi, S., Eto, T., Moriuchi, Y., Tanosaki, R., Kawano, F., Miyazaki, Y., Masuda, M., Nagafuji, K., Hara, M., Takanashi, M., Kai, S., Atsuta, Y., Suzuki, R., Kawase, T., Matsuo, K., Nagamura-Inoue, T., Kato, S., Sakamaki, H., Morishima, Y., Okamura, J., Ichinohe, T. & Uchiyama, T. (2010). Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood 116, 1369-76.
4. Yamashita, K., Miyoshi, T., Arai, T., Endo, N., Itoh, H., Makino, K., Mizugishi, K., Uchiyama, T. & Sasada, M. (2008). Ozone production by amino acids contributes to killing of bacteria. Proc Natl Acad Sci U S A 105, 16912-7.
5. Yamamoto, R., Nishikori, M., Kitawaki, T., Sakai, T., Hishizawa, M., Tashima, M., Kondo, T., Ohmori, K., Kurata, M., Hayashi, T. & Uchiyama, T. (2008). PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood 111, 3220-4.
6. Shirakawa, K., Takaori-Kondo, A., Yokoyama, M., Izumi, T., Matsui, M., Io, K., Sato, T., Sato, H. & Uchiyama, T. (2008). Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif. Nat Struct Mol Biol 15, 1184-91.