It is printed in the A4 size.To the laboratory site

 - Basic Medicine (Core Departments) - Infectious Diseases and Immunology
Immunology and Cell Biology
Immunology constitutes an essential part in almost every field of modern medicine, and understanding of immune mechanisms has greatly contributed to the medical progress in many aspects. Despite the amazing advances in immunology for recent decades, however, major immunological issues remain to be unveiled, and immunology continues to be one of the most mysterious and challenging fields in modern biology and medicine. Research efforts in our laboratory are focused on understanding the central issues in immunology, including the development of immune system, mechanisms of tumor immunity, autoimmunity and leukemia development.

  Nagahiro Minato, M.D., Ph.D.
Research and Education
Current major research activities in the laboratory are focused on two aspects; first, understanding of the mechanisms and regulation of normal immune system and elucidating how dysregulation of normal development leads to life-threatening diseases such as autoimmune diseases, immunodeficiency and leukemia; second, understanding of the mechanisms of possible immune surveillance against autonomously arising malignant cells and applying the principles for effectively controlling human cancer. We are studying these crucial issues with the use of feasible animal models including gene-engineered animals in close conditions to “reality” as much as possible. Our key word is “ nature, but not we, decides the way to go”. This laboratory is primarily responsible for the education of Immunology for both undergraduate and graduate students of Kyoto University School of Medicine. There are many graduate students at Master and PhD courses of both Graduate School of Medicine and Graduate School of Biostudies, including foreign students, and they are included in several specific research projects under the instruction of 4 faculty staff members with regular English-based laboratory meetings.

Immunology and Cell Biology
Professor Nagahiro Minato

Yasutoshi Agata,
Yoko Hamazaki
Joe Inoue
Associate Professor
Yoshimasa Tanaka
TEL +81-75-753-4659
FAX +81-75-753-4403
Recent Publications
1. Kawai. K. Hamazaki, Y., Fujita, H., Fujita, A., Sato, T., Moriwaki, K., Furuse, M. , Fujimoto, T., Agata, Y. and Minato, N. (2011) Claudin-4 is induced in thymocytes of late CD4/CD8 double positive stage by E2A and promotes alpha BetaT cell receptor–mediated positive selection. Proc. Nat. Acad. Sci. USA. in the press.
2. Shimatani, K., Nakashima, Y., Hattori, M., Hamazaki, Y., and Minato, N. (2009) Memory phenotype PD-1+ CD4+ T cells expressing C/EBP alpha underlie T cell immunodepression in senescence and leukemia. Proc. Nat. Acad. Sci. USA. 106;15807-15812.
3. Hamazaki, Y, Fujita, H, Kobayashi, T, Choi, Y, H. Scott, Matsumoto, M, and Minato, N. (2007) Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from claudin-expressing cells. Nature Immunol. 8:304-311.
4. Minato, N, K. Kometani, and M.Hattori. (2007) Regulation of immune responses and hematopoiesis by the Rap1 signal. (Review) Adv. Immunol. 93: 229-264.
5. Ishida, D., Su, L., Shinozuka, Y., Tamura,A., Katayama, Y., Kawai, Y., Wang, S-F, Taniwaki, M., Hamazaki, Y., Hattori, M., and Minato, N. (2006) Rap1 Signal Controls B Cell Receptor Repertoire and Generation of Self-reactive B1 Cells. Immunity, 24,417-427.
Myeloproliferative disorders by deregulated Rap signaling (from cover page of Cancer Cell)
Development thymic epithelial cells (from Nature Immunol.) 
Laboratory members