It is printed in the A4 size.To the laboratory site

 - Basic Medicine(Core Departments) - Basic Pathology
Pathology and Biology of Diseases
Pathology is the school of science that takes advantage of any methodology for the understanding of the diseases. Our laboratory has been achieving many feats in the experimental oncology such as the discovery of Fujinami Sarcoma Virus, which was named after the founder of our department, Professor Akira Fujinami. We succeed this tradition and attempt to decipher the enigma of cancer development by using variety of techniques, which includes Fluorescence resonance energy transfer (FRET) imaging, two-photon excitation fluorescence microscopy, and computer simulation.

Michiyuki Matsuda, M.D., Ph.D.
Professor
Research and Education
The basic concept of this department is the cancer research based on the morphological methods. We have been developing FRET probes for the monitoring of oncogene products in living cells. The first successful image of Ras activation reported in 2001 can be found in many textbooks of cell biology. To date this research group has been developed more than 20 probes for G proteins, kinases, and phospholipids. These probes are used to visualize the growth signal transduction cascades and to collect parameters that determine the property of this signaling system. Such parameters are invaluable in that they provide the foundation of the virtual cancer cells. Students in our department come from schools of medicine, biology, physics, and so on. They are enthusiastically learning not only modern molecular biology and pathology, but also bioimaging and system biology. We pay particular focus on the teaching of English communication. Many students present their data in the meetings abroad.


Pathology and Biology of Diseases
Professor ： Michiyuki Matsuda
Senior
　Lecturer
：
Etsuko Kiyokawa
TEL ： +81-75-753-4697(office), 9450 (laboratory)
FAX ： +81-75-753-4655 (office), 4698 (laboratory)
e-mail ： matsudam lif.kyoto-u.ac.jp
kiyokawalif.kyoto-u.ac.jp
URL ： http://iisi.path1.med.kyoto-u.ac.jp/
Activity change of Rac1 GTPase during cytokinesis of Hela cells
Kinetic simulation model of Ras/Raf/MEK/ERK cascade
Simulation model of EGF receptor signaling
Video image of glioma cell invasion into the brain
Recent Publications
1. Kitano M, Nakaya M, Nakamura T, Nagata S, and Matsuda M. Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature 453:241-245, 2008.
2. Aoki K, Nakamura T, Inoue T, Meyer T, and Matsuda M. An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of NGF-stimulated PC12 cells. J.Cell Biol. 177:817-827, 2007.
3. Takaya A, Kamio A, Masuda M, Mochizuki N, Sawa H, Sato M, Nagashima K, Mizutani A, Matsuno A, Kiyokawa E, and Matsuda M. R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol.Biol.Cell 18:1850-1860, 2007.
4. Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel AR, and Matsuda M. GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev. Cell 11: 411-421, 2006.
5. Terai K and Matsuda M. The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. EMBO J. 25: 3556-3564, 2006.